Effect of the extract of ivy leaves on the production of antimicrobial peptides in acute simple bronchitis in children
Background. Currently, there is a tendency to a chronicity of acute respiratory infections, which requires the development of medications to prevent its development. The purpose of the work was to study the clinical and immunological efficacy of the extract of ivy leaves in the treatment of acute simple bronchitis in children. Materials and methods. We have examined 40 children aged 2 to 6 years with acute simple bronchitis, 14 patients received Pectolvan Hedera. During the work, clinical and laboratory methods of investigation were used. The severity of the patient’s condition was assessed according to the Bronchitis severity score. The laboratory study included: general blood and urine test, the use of nasocytological, immunoassay methods. The etiological diagnosis was established on the basis of virological methods of investigation. When determining lactoferrin concentration, Human Lactoferrin HK329 Edition 06-16 set manufactured by Hycult Biotech (USA) was used, neutrophilic a-defensin (1–3) content — Human HNP HK317 Edition 08-16 reagents manufactured by Hycult Biotech (USA). Results. Acute bronchitis in the examined patients is caused by viral agents. In all children with acute simple bronchitis, the disease began acutely and manifested itself with catarrhal and general inflammatory syndromes. The use of Pectolvan Hedera expectorant in the therapy helped to reduce the clinical manifestations of the disease more rapidly, to prevent chronicity, was accompanied by a significant decrease in the number of leukocytes in the nasal mucosa and an increase in the lactoferrin content in the oropharyngeal secretions until the period of convalescence. Conclusions. Extract of ivy leaves is not only a symptomatic expectorant, but also a pathogenetic drug that can be considered a drug of choice in the treatment of acute simple bronchitis in children.
Full Text:PDF (Українська)
Abaturov AE, Babich VL, Tokareva NM. The expectorant therapy for acute respiratory infections in children. Zdorovʹe rebenka. 2018;5(13):478-483. doi: 10.22141/2224-05126.96.36.1998.141563. (in Russian).
Bekchanova YH, Abdalov ShU, Kurvandurdieva NK. Acute bronchitis in children and effective combined drugs used in this pathology. Current scientific research in the modern world. 2017;(24):87-89. (in Russian).
Dzhumagaziev AA. The use of immunomodulators and metabolites for the prevention of acute bronchitis and acute pneumonia in children. Novaja nauka: teoreticheskij i prakticheskij vzgljad. 2016;(117-3):44-45. (in Russian).
Kryuchko TO, Abaturov OE, Tkachenko OYa, Tokareva NM. Priority of using herbal medicines in the treatment of viral respiratory infections in children. Zdorovʹe rebenka. 2018;13(1):28-34. doi: 10.22141/2224-05188.8.131.528.127062. (in Russian).
Drago-Serrano ME, Campos-Rodríguez R, Carrero JC, de la Garza M. Lactoferrin: Balancing Ups and Downs of Inflammation Due to Microbial Infections. Int J Mol Sci. 2017 Mar 1;18(3). pii: E501. doi: 10.3390/ijms18030501.
Gepdiremen A, Mshvildadze V, Süleyman H, Elias R. Acute anti-inflammatory activity of four saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema. Phytomedicine. 2005 Jun;12(6-7):440-4. doi: 10.1016/j.phymed.2004.04.005.
Gualdi L, Mertz S, Gomez AM, Ramilo O, Wittke A, Mejias A. Lack of effect of bovine lactoferrin in respiratory syncytial virus replication and clinical disease severity in the mouse model. Antiviral Res. 2013 Aug;99(2):188-95. doi: 10.1016/j.antiviral.2013.05.013.
Hong EH, Song JH, Shim A, et al. Coadministration of Hedera helix L. Extract Enabled Mice to Overcome Insufficient Protection against Influenza A/PR/8 Virus Infection under Suboptimal Treatment with Oseltamivir. PLoS One. 2015 Jun 22;10(6):e0131089. doi: 10.1371/journal.pone.0131089.
Hwang SA, Kruzel ML, Actor JK. Recombinant human lactoferrin modulates human PBMC derived macrophage responses to BCG and LPS. Tuberculosis (Edinb). 2016 Dec;101S:S53-S62. doi: 10.1016/j.tube.2016.09.011.
Kardos P, Lehrl S, Kamin W, Matthys H. Assessment of the effect of pharmacotherapy in common cold/acute bronchitis - the Bronchitis Severity Scale. Pneumologie. 2014 Aug;68(8):542-6. doi: 10.1055/s-0034-1377332.
Kim HP, Lim H, Kwon YS. Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders. Biomol Ther (Seoul). 2017 Mar 1;25(2):91-104. doi: 10.4062/biomolther.2016.187.
Lang C, Röttger-Lüer P, Staiger C. A Valuable Option for the Treatment of Respiratory Diseases: Review on the Clinical Evidence of the Ivy Leaves Dry Extract EA 575®. Planta Med. 2015 Aug;81(12-13):968-74. doi: 10.1055/s-0035-1545879.
Li X, Liu D, Chen HL, Pan XH, Kong QY, Pang QF. Lactoferrin protects against lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol. 2012 Feb;12(2):460-4. doi: 10.1016/j.intimp.2012.01.001.
Moawad EM, Haron MA, Maher RM, et al. Cross-sectional evaluation of the Bronchitis Severity Score in Egyptian children: A move to reduce antibiotics. S Afr Med J. 2017 Mar 29;107(4):342-345. doi: 10.7196/SAMJ.2017.v107i4.11428.
Schaefer A, Kehr MS, Giannetti BM, Bulitta M, Staiger C. A randomized, controlled, double-blind, multi-center trial to evaluate the efficacy and safety of a liquid containing ivy leaves dry extract (EA 575®) vs. placebo in the treatment of adults with acute cough. Pharmazie. 2016 Sep 1;71(9):504-509. doi: 10.1691/ph.2016.6712.
Schulte-Michels J, Keksel C, Häberlein H, Franken S. Anti-inflammatory effects of ivy leaves dry extract: influence on transcriptional activity of NFκB. Inflammopharmacology. 2018 May 11. doi: 10.1007/s10787-018-0494-9.
Siqueiros-Cendón T, Arévalo-Gallegos S, Iglesias-Figueroa BF, García-Montoya IA, Salazar-Martínez J, Rascón-Cruz Q. Immunomodulatory effects of lactoferrin. Acta Pharmacol Sin. 2014 May;35(5):557-66. doi: 10.1038/aps.2013.200.
Timmer A, Günther J, Rücker G, Rücker G, Antes G, Kern WV. Pelargonium sidoides extract for acute respiratory tract infections. Cochrane Database Syst Rev. 2013 Oct 22;(10):CD006323. doi: 10.1002/14651858.CD006323.pub3.
Zeil S, Schwanebeck U, Vogelberg C. Tolerance and effect of an add-on treatment with a cough medicine containing ivy leaves dry extract on lung function in children with bronchial asthma. Phytomedicine. 2014 Sep 15;21(10):1216-20. doi: 10.1016/j.phymed.2014.05.006.
Zheng Y, Qin Z, Ye Q, et al. Lactoferrin suppresses the Epstein-Barr virus-induced inflammatory response by interfering with pattern recognition of TLR2 and TLR9. Lab Invest. 2014 Nov;94(11):1188-99. doi: 10.1038/labinvest.2014.105.
Copyright (c) 2018 CHILD`S HEALTH
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Publishing House Zaslavsky, 1997-2019