Effect of the extract of ivy leaves on the production of antimicrobial peptides in acute simple bronchitis in children

A.E. Abaturov, N.M. Tokareva, A.A. Nikulina


Background. Currently, there is a tendency to a chronicity of acute respiratory infections, which requires the development of medications to prevent its development. The purpose of the work was to study the clinical and immunological efficacy of the extract of ivy leaves in the treatment of acute simple bronchitis in children. Materials and methods. We have examined 40 children aged 2 to 6 years with acute simple bronchitis, 14 patients received Pectolvan Hedera. During the work, clinical and laboratory methods of investigation were used. The severity of the patient’s condition was assessed according to the Bronchitis severity score. The laboratory study included: general blood and urine test, the use of nasocytological, immunoassay methods. The etiological diagnosis was established on the basis of virological methods of investigation. When determining lactoferrin concentration, Human Lactoferrin HK329 Edition 06-16 set manufactured by Hycult Biotech (USA) was used, neutrophilic a-defensin (1–3) content — Human HNP HK317 Edition 08-16 reagents manufactured by Hycult Biotech (USA). Results. Acute bronchitis in the examined patients is caused by viral agents. In all children with acute simple bronchitis, the disease began acutely and manifested itself with catarrhal and general inflammatory syndromes. The use of Pectolvan Hedera expectorant in the therapy helped to reduce the clinical manifestations of the disease more rapidly, to prevent chronicity, was accompanied by a significant decrease in the number of leukocytes in the nasal mucosa and an increase in the lactoferrin content in the oropharyngeal secretions until the period of convalescence. Conclusions. Extract of ivy leaves is not only a symptomatic expectorant, but also a pathogenetic drug that can be considered a drug of choice in the treatment of acute simple bronchitis in children.


acute simple bronchitis; children; immunity; ivy leaf extract; lactoferrin; α-defensins


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