Modern concept of the brain-lung-thyroid syndrome and its pulmonary manifestations

O.L. Logvinova, M.A. Gonchar


This article is a review of the modern world literature on the brain-lung-thyroid syndrome in children. The authors focused on the etiology and features of ontogenesis of the involved organs in the presence of NKX2-1 gene mutation. Particular attention is paid to the clinical manifestations and early diagnosis of this syndrome in newborns and young children. Current options for the treatment of the brain-lung-thyroid syndrome are presented.


children; newborns; NKX2-1; TTF-1; interstitial lung diseases; respiratory distress syndrome; brain-lung-thyroid syndrome; review


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