Influence of interleukin-10 gene polymorphism on the course of cystic fibrosis in children
Background. Cystic fibrosis (CF) features depend on a number of gene modifiers. Interleukin-10 (IL-10) gene is a one of these gene modifiers. The purpose was to improve medical care for patients with CF by clarifying the pathogenetic role of the IL-10 gene polymorphism in the disease course. Materials and methods. Forty-two children with CF were examined with standard methods during the remission period. Detection of the G1082A polymorphism of the IL-10 gene was carried out using real time polymerase chain reaction. DNA was isolated from buccal epithelium cells. Results. Patients with IL-10 gene mutation (G1082A) were characterized by the earlier manifestation of intestinal symptoms, later manifestation of pulmonary signs, more severe course of CF (bronchiectasis (72 %) and lung fibrosis (95.4 %), severe liver lesions (36.4 %), a decrease in forced expiratory volume in one second (70.0 (65.0; 72.0) %)), Pseudomonas aeruginosa predominance (59.1 %) among respiratory pathological microorganisms in the sputum, immune status changes (an increase of the circulating immune complexes (8.65 (7.6; 10.55) units) and a decrease of spontaneous index of activated neutrophils test (0.31 (0.24; 0.78) units)). Conclusions. CF phenotype associated with the G1082A polymorphism of the IL-10 gene was examined.
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Bombieri C, Seia M, Castellani C. Genotypes and Phenotypes in Cystic Fibrosis and Cystic Fibrosis Transmembrane Regulator - Related Disorders. Semin Respir Crit Care Med. 2015 Apr;36(2):180-93. doi: 10.1055/s-0035-1547318.
Yokoyama E, Chávez-Saldana M, Orozco L, et al. Influence of SNPs in Genes that Modulate Lung Disease Severity in a Group of Mexican Patients with Cystic Fibrosis. Arch Med Res. 2018 Apr 24. pii: S0188-4409(18)30110-3. doi: 10.1016/j.arcmed.2018.04.010.
Flume PA, Mogayzel PJ Jr, Robinson KA, et al. Cystic fibrosis pulmonary guidelines: treatment of pulmonary exacerbations. Am J Respir Crit Care Med. 2009 Nov 1;180(9):802-8. doi: 10.1164/rccm.200812-1845PP.
Li W, Soave D, Miller M, et al. Unraveling the complex genetic model for cystic fibrosis: pleiotropic effects of modifier genes on early cystic fibrosis-related morbidities. Hum Genet. 2014 Feb;133(2):151-61. doi: 10.1007/s00439-013-1363-7.
Kuz'mina LP, Izmerova NI, Kolyaskina MM. Role of Interleukin-4, Interleukin-10, and Tumor Necrosis Factor-α Polymorphic Genes in the Pathogenesis of Occupational Allergic Dermatoses. Bull Exp Biol Med. 2015 Oct;159(6):779-81. doi: 10.1007/s10517-015-3074-7.
O'Neal WK, Knowles MR. Cystic Fibrosis Disease Modifiers: Complex Genetics Defines the Phenotypic Diversity in a Monogenic Disease. Annu Rev Genomics Hum Genet. 2018 Apr 25. doi: 10.1146/annurev-genom-083117-021329.
Koljubaeva SN, Gajvoronskij IN, Mjakoshina LA, et al. Investigation of polymorphisms of some genes of cytochrome P450, VCORC1, folate cycle, SSRDEL32, TNFA and IL-10 in community-acquired pneumonia. In: Сollection of proceedings of the IX Russian Scientific and Practical Conference with international participation. Molecular Diagnostics 2017. Moskow: Ylis; 2017. 61-62 pp. (In Russian).
Akparova AYU, Abdrakhmanova BM, Imanbay AK, et al. Association of Polymorphism of IL-10 and IL-17F with Chronic Obstructive Pulmonary Disease in the Kazakh Population. Veles. 2016;(31):10-12. (In Russian).
Babić Ž, Sabolić Pipinić I, Varnai VM, Kežić S, Macan J. Associations of TNFα -308G>A, TNFα -238G>A, IL-1α -889C>T and IL-10 -1082G>A Genetic Polymorphisms with Atopic Diseases: Asthma, Rhinitis and Dermatitis. Int Arch Allergy Immunol. 2016;169(4):231-40. doi: 10.1159/000445434.
Silva PC, Gomes AV, de Souza TK, et al. Association of SNP (-G1082A) IL-10 with increase in severity of periportal fibrosis in schistosomiasis, in the northeast of Brazil. Genet Test Mol Biomarkers. 2014 Sep;18(9):646-52. doi: 10.1089/gtmb.2014.0098.
Tesse R, Cardinale F, Santostasi T. Association of interleukin-10 gene haplotypes with Pseudomonas aeruginosa airway colonization in cystic fibrosis. J Cyst Fibros. 2008 Jul;7(4):329-32. doi:10.1016/j.jcf.2007.11.004.
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