Efficiency of using herbal immunomodulating drug for non-specific prevention of acute respiratory infections

А.Е. Abaturov, Т.А. Kryuchko


A study of 68 children aged 4 to 11 years showed that the application of BNO 1030 extract in the pre-epidemic period reduces the risk of acute respiratory infections. After the preventive use of BNO 1030 extract, subsequent acute respiratory infections are characterized by a mild and uncomplicated course, which usually does not require the prescription of antibiotic therapy. It has been established that BNO 1030 extract has an anti-inflammatory effect by increasing the production of the CD14 molecule and suppressing the activity of the NF-kB transcription factor.


acute respiratory infections; children; immunity; BNO 1030 extract; sCD14; TLR4; NF-kB


Arnold C, Chaffin MK, Cohen N, Fajt VR, Taylor RJ, Bernstein LR. Pharmacokinetics of gallium maltolate after intragastric administration in adult horses. Am J Vet Res. 2010 Nov;71(11):1371-6. doi: 10.2460/ajvr.71.11.1371.

Atala A. Re: Cellular Uptake and Anticancer Activity of Carboxylated Gallium Corroles. J Urol. 2016 Nov;196(5):1584-1585. doi: 10.1016/j.juro.2016.08.022.

Ballouche M, Cornelis P, Baysse C. Iron metabolism: a promising target for antibacterial strategies. Recent Pat Antiinfect Drug Discov. 2009 Nov;4(3):190-205.

Banin E, Lozinski A, Brady KM, et al. The potential of desferrioxamine-gallium as an anti-Pseudomonas therapeutic agent. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16761-6. doi: 10.1073/pnas.0808608105.

Bernstein LR. Ga Therapeutic Gallium Compounds. In: Gielen M, Tiekink ERT, editors. Metallotherapeutic Drugs and Metal‐Based Diagnostic Agents: The Use of Metals in Medicine, Ch 14. England: John Wiley & Sons, Ltd; 2005. 259-277 pp. doi: 10.1002/0470864052.ch14.

Bonchi C, Frangipani E, Imperi F, Visca P. Pyoverdine and proteases affect the response of Pseudomonas aeruginosa to gallium in human serum. Antimicrob Agents Chemother. 2015 Sep;59(9):5641-6. doi: 10.1128/AAC.01097-15.

Braun V, Pramanik A, Gwinner T, Köberle M, Bohn E. Sideromycins: tools and antibiotics. Biometals. 2009 Feb;22(1):3-13. doi: 10.1007/s10534-008-9199-7.

Chen M, Wang Y, Gilliard RJ Jr, Wei P, Schwartz NA, Robinson GH. Synthesis and molecular structure of an abnormal carbene-gallium chloride complex. Dalton Trans. 2014 Oct 14;43(38):14211-4. doi: 10.1039/c4dt00933a.

Chevalier S, Bouffartigues E, Bodilis J, et al. Structure, function and regulation of Pseudomonas aeruginosa porins. FEMS Microbiol Rev. 2017 Sep 1;41(5):698-722. doi: 10.1093/femsre/fux020.

Chitambar CR. Gallium and its competing roles with iron in biological systems. Biochim Biophys Acta. 2016 Aug;1863(8):2044-53. doi: 10.1016/j.bbamcr.2016.04.027.

Chitambar CR. The therapeutic potential of iron-targeting gallium compounds in human disease: From basic research to clinical application. Pharmacol Res. 2017 Jan;115:56-64. doi: 10.1016/j.phrs.2016.11.009.

Coates AR, Halls G, Hu Y. Novel classes of antibiotics or more of the same? Br J Pharmacol. 2011 May;163(1):184-94. doi: 10.1111/j.1476-5381.2011.01250.x.

DeLeon K, Balldin F, Watters C, et al. Gallium maltolate treatment eradicates Pseudomonas aeruginosa infection in thermally injured mice. Antimicrob Agents Chemother. 2009 Apr;53(4):1331-7. doi: 10.1128/AAC.01330-08.

Despaigne AA, Parrilha GL, Izidoro JB, et al. 2-Acetylpyridine- and 2-benzoylpyridine-derived hydrazones and their gallium(III) complexes are highly cytotoxic to glioma cells. Eur J Med Chem. 2012 Apr;50:163-72. doi: 10.1016/j.ejmech.2012.01.051.

Drake EJ, Duckworth BP, Neres J, Aldrich CC, Gulick AM. Biochemical and structural characterization of bisubstrate inhibitors of BasE, the self-standing nonribosomal peptide synthetase adenylate-forming enzyme of acinetobactin synthesis. Biochemistry. 2010 Nov 2;49(43):9292-305. doi: 10.1021/bi101226n.

Falagas ME, Skalidis T, Vardakas KZ, Legakis NJ; Hellenic Cefiderocol Study Group. Activity of cefiderocol (S-649266) against carbapenem-resistant Gram-negative bacteria collected from inpatients in Greek hospitals. J Antimicrob Chemother. 2017 Jun 1;72(6):1704-1708. doi: 10.1093/jac/dkx049.

Foley TL, Simeonov A. Targeting iron assimilation to develop new antibacterials. Expert Opin Drug Discov. 2012 Sep;7(9):831-47. doi: 10.1517/17460441.2012.708335.

García-Contreras R, Pérez-Eretza B, Lira-Silva E, et al. Gallium induces the production of virulence factors in Pseudomonas aeruginosa. Pathog Dis. 2014 Feb;70(1):95-8. doi: 10.1111/2049-632X.12105.

Ghazi IM, Monogue ML, Tsuji M, Nicolau DP. Pharmacodynamics of cefiderocol, a novel siderophore cephalosporin, explored in a pseudomonas aeruginosa neutropenic murine thigh model. Int J Antimicrob Agents. 2017 Oct 27. pii: S0924-8579(17)30372-2. doi: 10.1016/j.ijantimicag.2017.10.008.

Ghequire MG, De Mot R. Ribosomally encoded antibacterial proteins and peptides from Pseudomonas. FEMS Microbiol Rev. 2014 Jul;38(4):523-68. doi: 10.1111/1574-6976.12079.

Górska A, Sloderbach A, Marszałł MP. Siderophore-drug complexes: potential medicinal applications of the 'Trojan horse' strategy. Trends Pharmacol Sci. 2014 Sep;35(9):442-9. doi: 10.1016/

Gulick AM. Nonribosomal peptide synthetase biosynthetic clusters of ESKAPE pathogens. Nat Prod Rep. 2017 Aug 2;34(8):981-1009. doi: 10.1039/c7np00029d.

Hider RC, Kong X. Chemistry and biology of siderophores. Nat Prod Rep. 2010 May;27(5):637-57. doi: 10.1039/b906679a.

Hijazi S, Visca P, Frangipani E. Gallium-Protoporphyrin IX Inhibits Pseudomonas aeruginosa Growth by Targeting Cytochromes Front Cell Infect Microbiol. 2017 Jan 26;7:12. doi: 10.3389/fcimb.2017.00012.

Huayhuaz JA, Vitorino HA, Campos OS, Serrano SHP1, Kaneko TM2, Espósito BP. Desferrioxamine and desferrioxamine-caffeine as carriers of aluminum and gallium to microbes via the Trojan Horse Effect. J Trace Elem Med Biol. 2017 May;41:16-22. doi: 10.1016/j.jtemb.2017.01.006.

Ji C, Juárez-Hernández RE, Miller MJ. Exploiting bacterial iron acquisition: siderophore conjugates. Future Med Chem. 2012 Mar;4(3):297-313. doi: 10.4155/fmc.11.191.

Johnstone TC, Nolan EM. Beyond iron: non-classical biological functions of bacterial siderophores. Dalton Trans. 2015 Apr 14;44(14):6320-39. doi: 10.1039/c4dt03559c.

Kaneko Y, Thoendel M, Olakanmi O, Britigan BE, Singh PK. The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity. J Clin Invest. 2007 Apr;117(4):877-88. doi: 10.1172/JCI30783.

Kelson AB, Carnevali M, Truong-Le V. Gallium-based anti-infectives: targeting microbial iron-uptake mechanisms. Curr Opin Pharmacol. 2013 Oct;13(5):707-16. doi: 10.1016/j.coph.2013.07.001.

Kubista B, Schoefl T, Mayr L, et al. Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - synergism with autophagy inhibition. J Exp Clin Cancer Res. 2017 Apr 12;36(1):52. doi: 10.1186/s13046-017-0527-z.

Kumar K. A novel approach of 67-Gallium-citrate three-phase bone scan to diagnose bone infection: A report of three cases. Indian J Nucl Med. 2016 Oct-Dec;31(4):260-266. doi: 10.4103/0972-3919.190801.

Kurth C, Kage H, Nett M. Siderophores as molecular tools in medical and environmental applications. Org Biomol Chem. 2016 Sep 21;14(35):8212-27. doi: 10.1039/c6ob01400c.

Machado I, Marino LB, Demoro B, et al. Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents. Eur J Med Chem. 2014 Nov 24;87:267-73. doi: 10.1016/j.ejmech.2014.09.067.

McPherson CJ, Aschenbrenner LM, Lacey BM, et al. Clinically relevant Gram-negative resistance mechanisms have no effect on the efficacy of MC-1, a novel siderophore-conjugated monocarbam. Antimicrob Agents Chemother. 2012 Dec;56(12):6334-42. doi: 10.1128/AAC.01345-12.

Miethke M, Marahiel MA. Siderophore-based iron acquisition and pathogen control. Microbiol Mol Biol Rev. 2007 Sep;71(3):413-51. doi: 10.1128/MMBR.00012-07.

Minandri F, Bonchi C, Frangipani E et al. Promises and failures of gallium as an antibacterial agent. Future Microbiol. 2014;9(3):379-97. doi: 10.2217/fmb.14.3.

Moynié L, Luscher A, Rolo D, et al. Structure and Function of the PiuA and PirA Siderophore-Drug Receptors from Pseudomonas aeruginosa and Acinetobacter baumannii. Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02531-16. doi: 10.1128/AAC.02531-16.

Page MG. Siderophore conjugates. Ann N Y Acad Sci. 2013 Jan;1277:115-26. doi: 10.1111/nyas.12024.

Qi J, Zheng Y, Qian K, et al. Synthesis, crystal structure and antiproliferative mechanisms of 2-acetylpyridine-thiosemicarbazones Ga(III) with a greater selectivity against tumor cells. J Inorg Biochem. 2017 Dec;177:110-117. doi: 10.1016/j.jinorgbio.2017.09.012.

Rangel-Vega A, Bernstein LR, Mandujano-Tinoco EA, García-Contreras SJ, García-Contreras R. Drug repurposing as an alternative for the treatment of recalcitrant bacterial infections. Front Microbiol. 2015 Apr 9;6:282. doi: 10.3389/fmicb.2015.00282.

Reagan P, Pani A, Rosner MH. Approach to diagnosis and treatment of hypercalcemia in a patient with malignancy. Am J Kidney Dis. 2014 Jan;63(1):141-7. doi: 10.1053/j.ajkd.2013.06.025.

Rhomberg PR, Shortridge D, Huband MD, et al. Multilaboratory broth microdilution MIC reproducibility study for GSK3342830, a novel catecholcephem. In: American Society for Microbiology (ASM Microbe), 1–5 June 2017, New Orleans, Louisiana, USA. North Liberty (IA): JMI Laboratories; 2017.

Richter K, Thomas N, Zhang G, et al. Deferiprone and Gallium-Protoporphyrin Have the Capacity to Potentiate the Activity of Antibiotics in Staphylococcus aureus Small Colony Variants. Front Cell Infect Microbiol. 2017 Jun 22;7:280. doi: 10.3389/fcimb.2017.00280.

Tan L, Tao Y, Wang T, et al. Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections. J Med Chem. 2017 Apr 13;60(7):2669-2684. doi: 10.1021/acs.jmedchem.6b01261.

Thompson MG, Truong-Le V, Alamneh YA, et al. Evaluation of Gallium Citrate Formulations against a Multidrug-Resistant Strain of Klebsiella pneumoniae in a Murine Wound Model of Infection. Antimicrob Agents Chemother. 2015 Oct;59(10):6484-93. doi: 10.1128/AAC.00882-15.

Tripathi A, Schofield MM, Chlipala GE, et al. Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis. J Am Chem Soc. 2014 Jan 29;136(4):1579-86. doi: 10.1021/ja4115924.

Valappil SP, Ready D, Abou Neel EA, et al. Controlled delivery of antimicrobial gallium ions from phosphate-based glasses. Acta Biomater. 2009 May;5(4):1198-210. doi: 10.1016/j.actbio.2008.09.019.

Valappil SP, Yiu HH, Bouffier L, et al. Effect of novel antibacterial gallium-carboxymethyl cellulose on Pseudomonas aeruginosa. Dalton Trans. 2013 Feb 7;42(5):1778-86. doi: 10.1039/c2dt32235h.

Vila-Farres X, Chu J, Inoyama D, et al. Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters. J Am Chem Soc. 2017 Feb 1;139(4):1404-1407. doi: 10.1021/jacs.6b11861.

Wang W, Qiu Z, Tan H, Cao L. Siderophore production by actinobacteria. Biometals. 2014 Aug;27(4):623-31. doi: 10.1007/s10534-014-9739-2.

Wright H, Bonomo RA, Paterson DL. New agents for the treatment of infections with Gram-negative bacteria: restoring the miracle or false dawn? Clin Microbiol Infect. 2017 Oct;23(10):704-712. doi: 10.1016/j.cmi.2017.09.001.

Zanias S, Papaefstathiou GS, Raptopoulou CP, et al. Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes. Bioinorg Chem Appl. 2010;2010. pii: 168030. doi: 10.1155/2010/168030.

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