Neuroendocrine cell hyperplasia of infancy (review of modern literature — 2018)

O.L. Logvinova


The review deals with the systematization of mo­dern world ideas about pulmonary neuroendocrine cells and a disease associated with their hyperplasia — neuroendocrine hyperplasia in infants. The pathogenesis, clinical and instrumental diagnostic criteria are presented, as well as differential diagnosis of neuroendocrine hyperplasia of infancy and other interstitial diseases of the lungs in young children. An algorithm for the diagnosis, treatment at the present stage and the results of catamnestic observation of children suffered from neuroendocrine hyperplasia has been demonstrated.


neuroendocrine cell hyperplasia; infants; interstitial lungs diseases; children


Song H, Yao E, Lin C, Gacayan R, Chen MH, Chuang PT. Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17531-6. doi: 10.1073/pnas.1207238109.

Braverman NE, D'Agostino MD, Maclean GE. Peroxisome biogenesis disorders: Biological, clinical and pathophysiological perspectives. Dev Disabil Res Rev. 2013;17(3):187-96. doi: 10.1002/ddrr.1113.

Domnik NJ, Cutz E. Pulmonary neuroepithelial bodies as airway sensors: Putative role in the generation of dyspnea Curr Opin Pharmacol. 2011 Jun;11(3):211-7. doi: 10.1016/j.coph.2011.04.003.

Deterding R. Evaluating infants and children with interstitial lung disease. Semin Respir Crit Care Med. 2007 Jun;28(3):333-41. doi: 10.1055/s-2007-981654.

Cutz E, Yeger H, Pan J. Pulmonary neuroendocrine cell system in pediatric lung disease-recent advances. Pediatr Dev Pathol. 2007 Nov-Dec;10(6):419-35. doi: 10.2350/07-04-0267.1.

Lukkarinen H, Pelkonen A, Lohi J, et al. Neuroendocrine cell hyperplasia of infancy: a prospective follow-up of nine children. Arch Dis Child. 2013 Feb;98(2):141-4. doi: 10.1136/archdischild-2012-302115.

Gomes VC, Silva MC, Maia Filho JH, et al. Diagnostic criteria and follow-up in neuroendocrine cell hyperplasia of infancy: a case series. J Bras Pneumol. 2013 Sep-Oct;39(5):569-78. doi: 10.1590/S1806-37132013000500007.

Kuznetsova AA, Pakhomova AA, Petrova SI, Peshekhonova YuV. Neuroendocrine cell hyperplasia of infancy. Pediatrician (St. Petersburg), 2016;7(2):170-175. doi: 10.17816/PED72170-175. (in Russian).

Jiramethee N, Erasmus D, Nogee L, Khoor A.  Pulmonary Neuroendocrine Cell Hyperplasia Associated with Surfactant Protein C Gene Mutation. Case Rep Pulmonol. 2017;2017:9541419. doi: 10.1155/2017/9541419.

Carr LL, Kern JA, Deutsch GH. Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia and Neuroendocrine Hyperplasia of Infancy. Clin Chest Med. 2016 Sep;37(3):579-87. doi: 10.1016/j.ccm.2016.04.018.

Nevel RJ, Garnett ET, Schaudies DA, Young LR. Growth trajectories and oxygen use in neuroendocrine cell hyperplasia of infancy. Pediatr Pulmonol. 2018 May;53(5):656-663. doi: 10.1002/ppul.23958.

Houin PR, Deterding RR, Young LR. Exacerbations in neuroendocrine cell hyperplasia of infancy are characterized by increased air trapping. Pediatr Pulmonol. 2016 Mar;51(3):E9-12. doi: 10.1002/ppul.23347.

Caimmi S, Licari A, Caimmi D, et al. Neuroendocrine cell hyperplasia of infancy: an unusual cause of hypoxemia in children Italian. Ital J Pediatr. 2016 Sep 15;42(1):84. doi: 10.1186/s13052-016-0295-y.

Copyright (c) 2020 CHILD`S HEALTH

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2020


   Seo анализ сайта