Biological marker of the mucosal inflammation in children with skin symptoms of the food hypersensitivity

O.P. Pakholchuk, S.N. Nedelska


Background. Food hypersensitivity (FH) remains actual medical problem. Aim of the work was to study the prevalence, correlation of fecal calprotectin (FC), biological marker of the mucosal inflammation, with age, sex, course of the skin symptoms of FH in children. Materials and methods. One hundred two patients (51 (50 %) boys, 51 (50 %) girls) with skin symptoms of FH were included into the study, mean age was 25.36 [12.00; 60.00] months. FC was detected by Calprotectin RAPIDTEST (Italy). Results. Calprotectin was detected in feces in 45 % of patients (n = 46), 13 % of them were children aged up to 1 year, 47.82 % — from 1 to 3 years. The number of children with positive FC test didn’t differ in different age groups (Kruskal-Wallis ANOVA test H (4, n = 102) = 4.45, p > 0.05). FC test was more often positive in boys, but statistically significant gender difference was detected only among children aged 1–3 years (c2 = 9.09, р < 0.05). There was no correlation of FC with age (j < 0.01, p > 0.05) and sex (j = 0.006, p > 0.05), age of the first symptoms and duration of the disease (r = +0.06, p > 0.05 and r = +0.02, p < 0.05, respectively). Conclusions. 45 % of children with skin symptoms of FH have organic changes in the intestinal wall, which was proved by biological marker — FC. Such changes have no correlation with age, sex, age of the first symptoms and duration of the disease.


food hypersensitivity; children; mucosal barrier; calprotectin; mucosal inflammation


Zaikov SV. Food intolerance and food allergy in children. Dytiachyi likar. 2011;3:38-45. (In Ukrainian).

Beşer OF, Sancak S, Erkan T, Kutlu T, Cokuğraş H, Cokuğraş FÇ. Can Fecal Calprotectin Level Be Used as a Markers of Inflammation in the Diagnosis and Follow-Up of Cow’s Milk Protein Allergy? Allergy Asthma Immunol Res. 2014 Jan;6(1):33-8. doi: 10.4168/aair.2014.6.1.33.

Diamanti A1, Colistro F, Basso MS, et al. Clinical role of calprotectin assay in determining histological relapses in children affected by inflammatory bowel diseases. Inflamm Bowel Dis. 2008 Sep;14(9):1229-35. doi: 10.1002/ibd.20472.

Montalto M, Santoro L, Curigliano V, et al. Faecal calprotectin concentrations in untreated coeliac patients. Scand J Gastroenterol. 2007 Aug;42(8):957-61. doi: 10.1080/00365520601173632.

Baldassarre ME, Fanelli M, Lasorella ML, et al. Fecal calprotectin (FC) in newborns: is it a predictive marker of gastrointestinal and/or allergic disease? Immunopharmacol Immunotoxicol. 2011 Mar;33(1):220-3. doi: 10.3109/08923973.2010.486035.

Pezzilli R, Barassi A, Morselli-Labate AM, et al. Fecal calprotectin and elastase 1 determinations in patients with pancreatic diseases: a possible link between pancreatic insufficiency and intestinal inflammation. J Gastroenterol. 2007 Sep;42(9):754-60. doi: 10.1007/s00535-007-2086-0.

Lasson A, Strid H, Ohman L, et al. Fecal calprotectin one year after ileocaecal resection for Crohn's disease--a comparison with findings at ileocolonoscopy. J Crohns Colitis. 2014 Aug;8(8):789-95. doi: 10.1016/j.crohns.2013.12.015.

Johansson SG, Bieber T, Dahl R, et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol. 2004 May;113(5):832-6. doi: 10.1016/j.jaci.2003.12.591.

Johansson SG, Hourihane JO, Bousquet J, et al. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy. 2001 Sep;56(9):813-24.

Lehmann FS, Burri E, Beglinger C. The role and utility of faecal markers in inflammatory bowel disease. Therap Adv Gastroenterol. 2015 Jan;8(1):23-36. doi: 10.1177/1756283X14553384.

Osborne NJ, Ukoumunne OC, Wake M, Allen KJ. Prevalence of eczema and food allergy is associated with latitudein Australia. J Allergy Clin Immunol. 2012 Mar;129(3):865-7. doi: 10.1016/j.jaci.2012.01.037.

Konikoff MR, Denson LA. Role of fecal calprotectin as a biomarker of intestinal inflammation in inflammatory bowel disease. Inflamm Bowel Dis. 2006 Jun;12(6):524-34.

Smaldini PL, Trejo F, Cohen JL, Piaggio E, Docena GH. Systemic IL-2/anti-IL-2Ab complex combined with sublingual immunotherapy suppresses experimental food allergy in mice through induction of mucosal regulatory T cells. Allergy. 2018 Apr;73(4):885-895. doi: 10.1111/all.13402.

Zhu Q, Li F, Wang J, Ma J, Sheng X. Upregulation of calprotectin in mild IgE-mediated ovalbumin hypersensitivity. Oncotarget. 2017 Jun 6;8(23):37342-37354. doi: 10.18632/oncotarget.16954.

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