Biochemical indicators of oral fluid in school-age children with a combined course of caries and chronic generalized catarrhal gingivitis under the influence of treatment and prophylactic measures

I.A. Trubka


Background. During the emergence and development of primary dental children’s diseases, namely caries and gingivitis, certain changes in the composition, biological and biochemical features of the oral fluid are observed. Detection of such features enables to evaluate the state of the organs and tissues of the oral cavity, as well as to assess the influence of developed therapeutic and prophylactic methods and approaches. The purpose of the study is to evaluate changes in biochemical parameters of saliva among school-age children with caries and chronic generalized catarrhal gingivitis under the influence of developed therapeutic and prophylactic measures (TPM). Materials and methods. Clinical studies were conducted with the participation of children aged 7 to 15 years with pre-determination of calcium, phosphorus, acid and alkaline phosphatases, malondialdehyde and catalase levels in the oral fluid before TPM and one year after applying it three times. Results. The use of TPM increases the calcium content in the oral fluid. We achieved the two-three times higher results in the main treatment subgroups when correction of insufficient calcium supply was made by regulating the child’s eating and drinking regime and by additional prescription of combined calcium preparation. The study of acid and alkaline phosphatase confirm a significant increase of their activity among children from the main subgroups with subcompensated form of caries and chronic generalized catarrhal gingivitis at baseline and a significant decrease of these parameters when using TPM. Catalase activity and malondialdehyde level at baseline among children from the main treatment subgroups were significantly higher as compared to controls. Increased catalase activity and MDA decrease to the level of healthy children indicates the normalization of the antioxidant-prooxidant system function under the influence of TPM. Conclusions. The main biochemical indices of the oral fluid confirm the positive influence and effectiveness of developed TPM.


oral fluid; biochemical indicators; children

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