Background. Relevance is associated with a decrease in the number of breastfed children and the choice of breast milk substitute. Features of the composition and properties of the modern adapted formula based on goat milk — Nanny-1 with prebiotics allow it to be used in the nutrition of young infants. The purpose was to assess the clinical effectiveness of Nanny-1 formula with prebiotics in young infants with functional constipations. Materials and methods. We have examined 64 formula-fed children aged 1 to 6 months with functional constipations. Babies were divided into 2 groups: 32 of them received the adapted goat-milk-based formula Nanny-1 with prebiotics (group 1), and 32 children — cow-milk-based formula with prebiotics (group 2). The examination included laboratory studies, evaluation of weight/height parameters, dynamics of functional gastrointestinal disorders. Results. Patients of both groups had a stable increase in body weight and gain in height. After a month of taking Nanny-1 with prebiotics, the incidence of functional digestive disorders in infants of the first group decreased. The number of babies with positive dynamics of gastrointestinal disorders receiving cow-milk-based formula was less than in group 1. In most infants fed using goat-milk-based formula with a prebiotic complex, the bowel emptying was regular and soft, stool consistency improved, the number of defecations was 1–3 times a day, constipations continued in 15.6 % of children. In the group of babies who received cow-milk-based formula, constipations remained in 9 infants (28.1 %). Conclusions. Using Nanny-1 formula with prebiotics in the nutrition of infants promotes their normal physical development and a decrease in the incidence of functional constipations and other gastrointestinal disorders.
infants; goat milk; breast milk substitutes; functional constipation
Tkach SM. Roman criteria for IV functional gastrointestinal disorders: what's new in the latest version. Modern Gastroenterology. 2016;(4):116-122. (in Russian).
Hyman PE, Milla PJ, Benninga MA, Davidson GP, Fleisher DF, Taminiau J. Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology. 2006 Apr;130(5):1519-26. doi: 10.1053/j.gastro.2005.11.065.
Everhart JE, Ruhl CE. Burden of digestive diseases in the United States part II: lower gastrointestinal diseases. Gastroenterology. 2009 Mar;136(3):741-54. doi: 10.1053/j.gastro.2009.01.015.
Belousova OYu. The modern view on functional constipation in infants: features of feeding and principles of non-pharmacological correction. Zdorov'e rebenka. 2015;(60):140-148. doi: 10.22141/2224-05188.8.131.525.74997. (in Russian).
Lessen R, Kavanagh K. Position of the academy of nutrition and dietetics: promoting and supporting breastfeeding. J Acad Nutr Diet. 2015 Mar;115(3):444-9. doi: 10.1016/j.jand.2014.12.014.
Savino F, Benetti S, Liguori SA, Sorrenti M, Cordero Di Montezemolo L. Advances on human milk hormones and protection against obesity. Cell Mol Biol (Noisy-le-grand). 2013 Nov 3;59(1):89-98.
Johnston M, Landers S, Noble L, Szucs K, Viehmann L, Section on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics. 2012 Mar;129(3):e827-41. doi: 10.1542/peds.2011-3552.
Kozhimannil KB, Jou J, Attanasio LB, Joarnt LK, McGovern P. Medically complex pregnancies and early breastfeeding behaviors: a retrospective analysis. PLoS One. 2014 Aug 13;9(8):e104820. doi: 10.1371/journal.pone.0104820.
Borovik TE, Lukoyanova OL, Semenova NN, et al. Experience of usage of adapted goat milk formula in nutrition of healthy infants during first six months of life. Voprosy Sovremennoi Pediatrii. 2014;13(2):44-54. (in Russian).
Voitava A, Mikulchyk N. Use of goat milk and new formulas based on it in nutrition of infants. Mezhdunarodnye obzory: klinicheskaia praktika i zdorov'e. 2015;(15):18-37. (in Russian).
Bulatova EM, Shestakova MD, Pirtskheleva TL. Effektivnost' ispol'zovaniia spetsializirovannykh produktov na osnove koz'ego moloka dlia vskarmlivaniia detei rannego vozrasta: metodicheskie rekomendatsii [Efficiency of using specialized products based on goat milk for feeding young children: methodical recommendations]. Saint-Petersburg; 2006. 20 p. (in Russian).
Malanicheva TG, Faizullina RA, Ziatdinova NV, Denisova SN. Ratsional'noe pitanie rebenka pervogo goda zhizni, zabolevaniia zheludochno-kishechnogo trakta, biliarnoi sistemy i organov dykhaniia: posobie po detskim bolezniam. Chast' 1 [Rational nutrition of the child of the first year of life, diseases of the gastrointestinal tract, biliary system and respiratory system: a guide to childhood illnesses. Part 1]. Kazan: Meditsina; 2013. 69 p . (in Russian).
Borovik TE, Semenova NN, Lukoyanova OL, et al. On the possibility of goat's milk and adapted goat milk formulas usage in children feeding. Voprosy Sovremennoi Pediatrii. 2013;12(1):8-16. (in Russian).
Tutel'ian VA, Kon' IIa, editors. Detskoe pitanie: rukovodstvo dlia vrachei [Baby food: a guide for doctors]. Moscow: MIA; 2015. 309-311 pp. ( in Russian).
Haenlein GFH. Goat milk in human nutrition. Small Ruminant Research. 2004 Feb;51(2):155-163. doi: 10.1016/j.smallrumres.2003.08.010.
Skidan IN, Gulyaev AE, Kaznacheev KS. Milk fat globules, as determinants of the nutritional and biological value of goat milk. Problems of Nutrition. 2015;84(2):81-95. (in Russian).
Zou X, Huang J, Jin Q, et al. Lipid composition analysis of milk fats from different mammalian species: potential for use as human milk fat substitutes. J Agric Food Chem. 2013 Jul 24;61(29):7070-80. doi: 10.1021/jf401452y.
Prosser С. Composition and clinical evidence of the safety and efficacy of an infant formula based on goat milk. Rossiyskiy Vestnik Perinatologii i Pediatrii. 2013;58(5):15-22. (in Russian).
Albrecht S, Lane JA, Marino K, et al. A comparative study of free oligosaccharides in the milk of domestic animals. Br J Nutr. 2014 Apr 14;111(7):1313-28. doi: 10.1017/S0007114513003772.
Musilova S, Rada V, Vlkova E, Bunesova V. Beneficial effects of human milk oligosaccharides on gut microbiota. Benef Microbes. 2014 Sep;5(3):273-83. doi: 10.3920/BM2013.0080.
Oozeer R, van Limpt K, Ludwig T, et al. Intestinal microbiology in early life: Specific prebiotics can have similar functionalities as human-milk oligosaccharides. Am J Clin Nutr. 2013 Aug;98(2):561S-71S. doi: 10.3945/ajcn.112.038893.
Kaznacheev KS, Kaznacheeva LF, Skidan IN, Cheganova IuV. Influence of milk mixture based on goat’s milk with prebiotics on forming healthy digestion in children in their first year. Lechaschii Vrach. 2015;(9):37-41. (in Russian).
Michaelsen KF, Greer FR. Protein needs early in life and long-term health. Am J Clin Nutr. 2014 Mar;99(3):718S-22S. doi: 10.3945/ajcn.113.072603.
Hochwallner H, Schulmeister U, Swoboda I, Spitzauer S, Valenta R. Cow’s milk allergy: From allergens to new forms of diagnosis, therapy and prevention. Methods. 2014 Mar 1;66(1):22-33. doi: 10.1016/j.ymeth.2013.08.005.
Nowak-Wegrzyn A, Kate Y, Soneil Mehr S, Koletzkon S. Non-lgE-mediated gastrointestinal food allergy. J Allergy Clin Immunol. 2015 May;135(5):1114-24. doi: 10.1016/j.jaci.2015.03.025.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on the essential composition of infant and follow‐on formulae. EFSA Journal 2012;10(3):2603. doi: 10.2903/j.efsa.2012.2603.
Martin CR, Ling P-R, Blackburn GL. Review of Infant Feeding: Key Features of Breast Milk and Infant Formula. Nutrients. 2016;8(5):279. doi:10.3390/nu8050279.
Marushko YV, Moskovenko ED. Use of infant formula based on goat for infant nutrition. Sovremennaya pediatriya. 2017;(83):76-82. (in Russian).
Turck D. Cow’s milk and goat’s milk. World Rev Nutr Diet. 2013;108:56-62. doi: 10.1159/000351485.