Priority of using herbal medicines in the treatment of viral respiratory infections in children
Background. Today, more than 80 % of the world population use herbal medicines. They have different therapeutic effects influencing the whole body. The good efficiency and tolerability of drugs containing Pelargonium sidoides is confirmed by clear scientific criteria and clinical trial data. The purpose of our research was to study the clinical efficiency and safety of the herbal medicine Papalor (Pelargonium sidoides) in the treatment of children with acute respiratory viral infections. Materials and methods. The clinical study included 67 boys and 53 girls aged 1 to 12 years. All children were divided into three age groups: 1–2, 3–5 and 6–12 years. Patients of the main group (n = 60) received Papalor, patients of the control group (n = 60) took only symptomatic treatment. The greatest number of children aged 3 to 5 years. Nosological manifestations of acute respiratory viral infections were nasopharyngitis, acute bronchitis and sinusitis. According to the study design, there were three control visits. Results. Analysis of the general criteria of acute respiratory viral infections revealed that the average duration of fever in patients of the main group was 2.7 days, in the control group — 3.4 days, symptoms of intoxication — 2.2 days and 2.9 days, respectively. Catarrhal presentations (runny nose, cough, sore throat) lasted for 4.2 days in patients of the main group, in controls — 4.6 days. More than 60 % of patients in both groups had acute bronchitis. At the beginning of treatment, the average level of Bronchitis Severity Score in both groups was almost the same. Already in 3–5 days, there was a significant difference in favor of the main group (p < 0.001), and by the end of treatment (day 7), it was even more expressed. From the start of therapy to its completion, Bronchitis Severity Score improved by 7.4 ± 1.8 in Pelargonium sidoides group compared with 5.2 ± 1.7 in the control group. Conclusions. A clinical study of Papalor effectiveness in the treatment of acute respiratory viral infections in children has shown reliable clinical results. The pronounced antiviral, moderate bacteriostatic effects, as well as mucociliary and anti-inflammatory properties of Papalor allowed using it both in comprehensive treatment and as a monotherapy.
Full Text:PDF (Українська)
Maydannik VG, Mityuryaeva IO, Ababcov VV, Borzenko IO, Molochek NV, Rybachok OV. Clinical and laboratory parameters of efficacy and safety of physiotherapy treatment of acute bronchitis in children from the perspective of evidence-basewd medicine. Problemy ekologichnoi' ta medychnoi' genetyky i klinichnoi' imunologii'. 2012;(110):377-390. (in Ukrainian).
Riley DS, Lizogub VG, Zimmermann A, Funk P, Lehmacher W. Efficacy and tolerability of high-dose Pelargonium Extract in patients with the common cold. Altern Ther Health Med. 2017 Oct 2. pii: AT5618. PMID: 29055287.
Tahan F, Yaman M. Can the Pelargonium sidoides root extract EPs® 7630 prevent asthma attacks during viral infections of the upper respiratory tract in children? Phytomedicine. 2013 Jan 15;20(2):148-50. doi: 10.1016/j.phymed.2012.09.022.
Matthys H, Funk P. Pelargonium sidoides preparation EPs 7630 in COPD: health-related quality-of-life and other patient-reported outcomes in adults receiving add-on therapy. Curr Med Res Opin. 2018 Jan 18:1-7. doi: 10.1080/03007995.2017.1416344.
Kardos P, Lehrl S, Kamin W, Matthys H. Assessment of the effect of pharmacotherapy in common cold/acute bronchitis - the bronchitis severity scale (BSS). Pneumologie. 2014 Aug;68(8):542-6. doi: 10.1055/s-0034-1377332.
Timmer A, Günther J, Rücker G, Motschall E, Antes G, Kern WV. Pelargonium sidoides extract for acute respiratory tract infections. Cochrane Database Syst Rev. 2013 Oct 22;(10):CD006323. doi: 10.1002/14651858.CD006323.pub3.
Copyright (c) 2018 CHILD`S HEALTH
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Publishing House Zaslavsky, 1997-2019