On vitamin D-dependent regulation of local mechanisms of non-specific defense in children with connective tissue dysplasia

L.I. Omelchenko, O.M. Mukvich, O.V. Lavrenchuk

Abstract


Parameters of non-specific immunity (human β-defensin 2 (HBD-2), lysozyme) were evaluated in local secretions of 127 children aged 11–17 years with phenotypic connective tissue dysplasia (CTD), with respect to the vitamin D supplementation. The lowest concentration of HBD-2 in local secretion was found in children with CTD and vitamin D deficiency (VDD) that is an indication of the vitamin D-dependent regulation of anti-microbal peptide production in epitheliocytes of the intestinal mucosa. The VDD is accompanied by the deficiency of non-specific humoral immune response (decreased lysozyme in saliva and coprofiltrate) in children with CTD. The deficiency is in direct dependency with vitamin D concentration and lysozyme (r = 0.65) that indicates the congenital insufficiency of synthesis or increased depletion of defense mucosal function in children with impaired collagen synthesis in basal membranes confirming that lysozyme concentration depends on the vitamin D supplementation.

Keywords


vitamin D; connective tissue dysplasia; antimicrobial peptides; children

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DOI: https://doi.org/10.22141/2224-0551.12.8.2017.119244

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