The influence of recovery treatment on the immune status of children with recurrent respiratory infections

O.I. Lemko, S.V. Lukashchuk, N.V. Vantyukh, M.I. Popadinets

Abstract


Background. Recurrent respiratory diseases are the most common pathology of childhood, they may be accompanied by suppression of the immune system and form the basis for the development of chronic inflammatory processes in the bronchopulmonary system at older age. Materials and methods. 58 sickly children and 61 patients aged 6–11 years with recurrent bronchitis were observed, the children were beyond the acute period. The phagocytic activity of neutrophils and monocytes and their phagocytic number, as well as the number of CD3+-, CD4+-, CD8+-cells with the ratio of CD4+- to CD8+-lymphocytes were determined. Treatment was carried according to three sets. The first one included 18 sessions of haloaerosol therapy. The second one provided a shortened course of haloaerosol therapy with the prescription of singlet-oxygen therapy, the third was conducted similarly to the second one with the additional prescription of vibroacoustic influence on the chest. Results. It was found that disturbances of nonspecific defense persist in the examined children beyond the acute period, which are manifested by a significant decrease in the absorption properties of neutrophils and monocytes. There were also changes in cellular immunity with manifestation of imbalance in the main subpopulations of T-lymphocytes and a significant decrease in the CD4+-/CD8+-lymphocytes ratio, more pronounced in patients with recurrent bronchitis. These changes indicate the need for immunorehabilitation treatment. Haloaerosol therapy in both groups of children leads to a significant improvement or normalization of the absorption properties of neutrophils and monocytes, and also helps to eliminate T-cell imbalance and to direct T-cell differentiation into the normal course. In sickly children, the increase in immunorehabilitation effects is possible with the use of one or two additional curative factors, which enables to reduce the course of haloaerosol therapy to 13 sessions. In patients with recurrent bronchitis, the most significant immunorehabilitation effect was achieved only by using two therapeutic factors on the background of the reduced regimen of haloaerosol therapy. Conclusions. The use of haloaerosol therapy in the recovery treatment of children with frequent and recurrent respiratory diseases provides a pronounced immunocorrective effect.

Keywords


children; recovery treatment; haloaerosol therapy; respiratory infections

References


Martinez FD. Genes, environments, development and asthma: a reappraisal. Eur Respir J. 2007 Jan;29(1):179-84. doi: 10.1183/09031936.00087906.

Jesenak M, Majtan J, Rennerova Z, Kyselovic J, Banovcin P, Hrubisko M. Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. Int Immunopharmacol. 2013 Feb;15(2):395-9. doi: 10.1016/j.intimp.2012.11.020.

Slatter MA, Gennery AR. Clinical immunology review series: an approach to the patient with recurrent infections in childhood. Clin Exp Immunol. 2008 Jun;152(3):389-396. doi: 10.1111/j.1365-2249.2008.03641.x.

Lemko OI, Lukashchuk SV, Vantyukh NV. Possibilities of haloaerosoltherapy in the recovery treatment of children with frequent and recurrent respiratory diseases. Sovremennaya Pediatriya. 2016;8(80):74-77. (in Russian).

Boiarskaia LN, Kotlova IuV, Gerasimchuk TS. Modern conceptions of reccurent respiratory deseases in infants (publice review). Sovremennaya pediatriya. 2011;6(40):194-197. (in Russian).

Verhagen LM, de Groot R. Recurrent, protracted and persistent lower respiratory tract infection: A neglected clinical entity. J Infect. 2015 Jun;71 Suppl 1:S106-11. doi: 10.1016/j.jinf.2015.04.011.

Lemko IS, Lemko OI. Speleotherapy and galorezoolterapy in Transcarpathia - becoming, present, prospects. In: Savchenko VM, Ezhov VV, editors. Aktual'nye voprosy kurortologii, fizioterapii i meditsinskoi reabilitatsii: Trudy. Tom 24: Materialy nauchno- prakticheskoj konferencii Aktual'nye voprosy fizioterapii i kurortologii [Topical issues of balneology, physiotherapy and medical rehabilitation: Proceedings. Vol 24: Proceedings of the scientific and practical conference Actual questions of physiotherapy and balneology, 2013 Oct 10-11, Yalta, Crimea]. Yalta: NII fiz. metodov lechenija i med. klimatologii im. I. M. Sechenova; 2013. 132-138 pp.

Yulish YeI, Yaroshenko SYa. Sickly children and pediatrician’s approach. Zdorov'ye Rebenka. 2013;6(49):70-76. (in Russian).

Lemko OI, Lemko IS. Sposib vidnovljuval'nogo likuvannja chasto hvorijuchyh ditej ta ditej hvoryh na recydyvujuchyj bronhit [Method of restorative treatment of sickly children and children with recurrent bronchitis]. Patent UA, no u 2016 00972, 2016.

Khan MA, Vahova EL. Health technologies in pediatrics. Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kul'tury. 2012;89(4):53-56. (in Russian).

Endre L. Theoretical basis and clinical benefits of dry salt inhalation therapy. Orv Hetil. 2015 Oct 11;156(41):1643-52. doi: 10.1556/650.2015.30267. (in Hungarian).

Raniszewska A, Górska E, Kotuła I, Stelmaszczyk-Emmel A, Popko K, Ciepiela O. Recurrent respiratory tract infections in children – analysis of immunological examinations. Cent Eur J Immunol. 2015; 40(2):167-173. doi: 10.5114/ceji.2015.52830.

Cheemarla NR, Baños-Lara MDR, Naidu S, Guerrero-Plata A. Neutrophils regulate the lung inflammatory response via γδ T cell infiltration in an experimental mouse model of human metapneumovirus infection. J Leukoc Biol. 2017 Jun;101(6):1383-1392. doi: 10.1189/jlb.4A1216-519RR.

Koskenvuo M, Milttinen M, Rahiala J, et al. Respiratory viral infections in children with leukemia. Pediatr Infect Dis J. 2008 Nov;27(11):974-80. doi: 10.1097/INF.0b013e31817b0799.

Mukvich OM, Omel'chenko LI. Prevention of recurrent acute respiratory infections in school-age children. Dytjachyj likar. 2013;6(27):65-70. (in Ukrainian).

Khoroshilova NV. Probiotics and Bacterial Immunomodulators for Prevention of Respiratory Infections. Voprosy Sovremennoi Pediatrii. 2014;13(4):93-95. (in Russian).

EngelaAU, Hoogduijn MJ, Boer K, et al. Human adipose-tissue derived mesenchymal stem cells induce functional de-novo regulatory T cells with methylated FOXP3 gene DNA. Clin Exp Immunol. 2013 Aug; 173(2):343-354. doi: 10.1111/cei.12120.

Lavrenchuk OV. Immunorehabilitation of children with chronic recurrent pyelonephritis. Sovremennaya pediatriya. 2015;1(65):120-125. (in Russian).

Tregoning JS, Schwarze J. Respiratory viral infections in infants: causes, clinical symptoms, virology and immunology. Clin Microbiol Rev. 2010 Jan; 23(1):74-98. doi: 10.1128/CMR.00032-09.

Kendirli T, Ikincioğullari A, Doğu F, Babacan E. Peripheral blood lymphocyte subsets in children with frequent upper respiratory tract infections. Turk. J. Pediatr. 50(1):63-66. PMID: 18365594.

Likhanova UV, Kondrat'eva EI, Stepanenko NP, Shakhova SS, Kurts IA. The rehabilitative treatment of the frequently ill children presenting with chronic infectious foci in the nasopharynx. Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kul'tury. 2014;91(2):33-37. (in Russian).

Shcherbak IB. Bion Z Kid in the complex immunorehabilitation of often ill children. Ukrainskii meditsinskii zhurnal. 2014;2:78-81. (in Russian).

Maiorov RV, Chereshneva MV, Verzilin SD, Chereshnev VA. Efficiency of some immunomodulatory drugs for prevention of respiratory infections and their complications in young schoolchildren with recurrent respiratory infections. Meditsinskaya immunologiya. 2013;15(3):255-262. (in Russian).

Gelardi M, Iannuzzi L, Greco Miani A, et al. Double-blind placebo-controlled randomized clinical trial on the efficacy of Aerosal in the treatment of sub-obstructive adenotonsillar hypertrophy and related diseases. nt J Pediatr Otorhinolaryngol. 2013 Nov;77(11):1818-24. doi: 10.1016/j.ijporl.2013.08.013.




DOI: https://doi.org/10.22141/2224-0551.12.7.2017.116182

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