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Background. Food allergy is an emerging health problem in the last years. There are many different questionnaires that could be used to establish health-related quality of life in patients with food allergy and gastroduodenal pathology. The objective was to study the age-related dynamics of the allergic-specific IgE level in children with food allergy and pathology of upper gastrointestinal tract. Materials and methods. On the base of the Chernivtsy Regional Children’s Hospital, 76 children with food allergy associated with the pathology of upper gastrointestinal tract aged 7 to 18 years were examined. A clinical and laboratory examination was conducted twice. The allergen-specific IgE levels were measured in blood samples. The test was considered positive at IgE levels > 0.35 kU/l. Results. Тhe age-related dynamics of IgE-positive responses was detected. The frequency of IgE-positive responses was higher in older children. Different groups of food allergens provoke sensibilization in children during their life. The allergen-specific IgE index ranged from 0.56 to 458 kU/l, with an average value of 286.7 ± 22.3 kU/l. The IgE index increased with age and more often occurred in children with chronic gastroduodenitis — 90.6 %. Conclusions. Factors of food allergy in children are irrational feeding during the first year of life and diseases of the gastrointestinal tract in older children. Age characteristics of IgE production require a differentiated diagnosis and treatment approach.
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. Werfel T, Asero R, Ballmer-Weber BK, et al. Position paper of the EAACI: Food allergy due to immunological cross-reactions with common inhalant allergens. Allergy. 2015;70(9):1079-1090. doi: 10.1111/all.12666.
Huang YJ, Marsland BJ, Bunyavanich S, et al. The microbiome in allergic disease: Current understanding and future opportunities-2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology. J Allergy Clin Immunol. 2017 Apr;139(4):1099-1110. doi: 10.1016/j.jaci.2017.02.007.
Lee SH, Gong YN, Ryoo E. Clostridium difficile colonization and/or infection during infancy and the risk of childhood allergic diseases. Korean J Pediatr. 2017 May; 60(5):145-150. doi: 10.3345/kjp.2017.60.5.145.
Nucera E, Rizzi A, Buonomo A, et al. The clinical meaning of positive latex sIgE in patients with food/pollen adverse reactions. Int J Immunopathol Pharmacol. 2012 Apr-Jun;25(2):445-53. doi: 10.1177/039463201202500214.
Blanchard C. A history into genetic and epigenetic evolution of food tolerance: how humanity rapidly evolved by drinking milk and eating wheat. Curr Opin Allergy Clin. Immunol. 2017Dec;17(6):460-464. doi: 10.1097/ACI.0000000000000397.
Sorokman TV, Popelyuk OMV, Lozyuk IA. Peculiarities of the course of combined pathology of the upper gastrointestinal tract and allergic dermatoses in children. Zdorov'e rebenka. 2017;12(3):324-328. DOI:10.22141/2224-0522.214.171.1247.104221. (In Ukrainian).
Sazanova NE, Shabunina EI, Lavrova AE, Borisova EY, Shirokova NY. Clinico-morphological features and mucosal immunity in children with chronic gastroduodenitis and food allergies. Pediatria Journal named after G.N.Speransky. 2014;93(6):17-23. doi:10.24110/0031-403X-2014-93-6-17-2. (In Russian).
Liacouras C, Furuta G, Hirano I, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011 Jul;128(1):3-20.e6; quiz 21-2. doi: 10.1016/j.jaci.2011.02.040.
Spergel J, Brown-Whitehorn T, Cianferoni A, et al. Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet. J Allergy Clin Immunol. 2012 Aug;130(2):461-7.e5. doi: 10.1016/j.jaci.2012.05.021.
Schoos A-MM, Chawes BLK, Følsgaard NV, Samandari N, Bønnelykke K, Bisgaard H. Disagreement between skin prick test and specific IgE in young children. Allergy. 2015 Jan;70(1):41-8. doi: 10.1111/all.12523.