Nosospecific features of redox processes in bronchial asthma and chronic obstructive pulmonary disease

О.E. Abaturov, О.P. Volosovets, T.P. Borysova


The literature review presents current data on the specific features of oxidative stress, the functional activity of the antioxidant system and development of the inflammatory process in bronchial asthma and chronic obstructive pulmonary disease.


diseases of the respiratory system; antioxidant system; review


Goven D, Boutten A, Leçon-Malas V, et al. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Thorax. 2008 Oct;63(10):916-24. doi: 10.1136/thx.2007.091181. Epub 2008 Jun 17.

Bentley AR, Emrani P, Cassano PA. Genetic variation and gene expression in antioxidant related enzymes and risk of COPD: a systematic review. Thorax. 2008 Nov;63(11):956-61. doi: 10.1136/thx.2007.086199. Epub 2008 Jun 19.

Li MH, Jang JH, Na HK, Cha YN, Surh YJ. Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress inducesexpression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling. J Biol Chem. 2007 Sep 28;282(39):28577-86. Epub 2007 Aug 5. doi: 10.1074/jbc.M701916200.

Cho YS, Moon HB. The role of oxidative stress in the pathogenesis of asthma. Allergy Asthm Immunol Res. 2010 Jul;2(3):183-7. doi: 10.4168/aair.2010.2.3.183. Epub 2010 Apr 29.

Comhair SA, Erzurum SC. Redox control of asthma: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal. 2010 Jan;12(1):93-124. doi: 10.1089/ARS.2008.2425.

Comhair SA, Ricci KS, Arroliga M, et al. Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma. Am J Respir Crit Care Med. 2005 Aug 1;172(3):306-13. Epub 2005 May 5. doi: 10.1164/rccm.200502-180OC.

Malhotra D, Thimmulappa R, Navas-Acien A, et al. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med. 2008 Sep 15;178(6):592-604. doi: 10.1164/rccm.200803-380OC. Epub 2008 Jun 12.

Dozor AJ. The role of oxidative stress in the pathogenesis and treatment of asthma. Ann N Y Acad Sci. 2010 Aug;1203:133-7. doi: 10.1111/j.1749-6632.2010.05562.x. doi:10.1111/j.1749-6632.2010.05562.x.

Suzuki M, Betsuyaku T, Ito Y, et al. Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2008 Dec;39(6):673-82. doi: 10.1165/rcmb.2007-0424OC. Epub 2008 Jun 19.

Nagai K, Betsuyaku T, Suzuki M, et al. Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderatechronic obstructive pulmonary disease. Antioxid Redox Signal. 2008 Apr;10(4):705-14. doi: 10.1089/ars.2007.1941.

Imaoka H, Hoshino T, Okamoto M, et al. Endogenous and exogenous thioredoxin 1 prevents goblet cell hyperplasia in a chronic antigen exposure asthma model. Allergol Int. 2009 Sep;58(3):403-10. doi: 10.2332/allergolint.09-OA-0086. Epub 2009 Jun 25.

Cepelak I, Dodig S, Romic D, Ruljancic N, Popovic-Grle S, Malic A. Enzyme catalytic activities in chronic obstructive pulmonary disease. Arch Med Res. 2006 Jul;37(5):624-9. doi: 10.1016/j.arcmed.2006.01.004.

Won HY, Jang EJ, Min HJ, Hwang ES. Enhancement of Allergen-induced Airway Inflammation by NOX2 Deficiency. Immune Netw. 2011 Jun;11(3):169-74. doi: 10.4110/in.2011.11.3.169. Epub 2011 Jun 30.

Yamada Y, Nakamura H, Adachi T, et al. Elevated serum levels of thioredoxin in patients with acute exacerbation of asthma. Immunol Lett. 2003 Apr 3;86(2):199-205. PMID: 12644323.

Pierrou S, Broberg P, O'Donnell RA, et al. Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2007 Mar 15;175(6):577-86. Epub 2006 Dec 7. doi: 10.1164/rccm.200607-931OC.

Yao H, Arunachalam G, Hwang JW, et al. Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15571-6. doi: 10.1073/pnas.1007625107. Epub 2010 Aug 16.

Oberley-Deegan RE, Regan EA, Kinnula VL, Crapo JD. Extracellular superoxide dismutase and risk of COPD. COPD. 2009 Aug;6(4):307-12. PMID: 19811392.

Fischer BM, Pavlisko E, Voynow JA. Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation. Int J Chron Obstruct Pulmon Dis. 2011;6:413-21. doi: 10.2147/COPD.S10770. Epub 2011 Aug 5.

Foster MW, Hess DT, Stamler JS. Protein S-nitrosylation in health and disease: a current perspective. Trends Mol Med. 2009 Sep;15(9):391-404. doi: 10.1016/j.molmed.2009.06.007. Epub 2009 Aug 31.

Slager RE, Hawkins GA, Li X, Postma DS, Meyers DA, Bleecker ER. Genetics of asthma susceptibility and severity. Clin Chest Med. 2012 Sep;33(3):431-43. doi: 10.1016/j.ccm.2012.05.005. Epub 2012 Jul 7.

Wu H, Romieu I, Sienra-Monge JJ, Estela Del Rio-Navarro B, et al. Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. J Allergy Clin Immunol. 2007 Aug;120(2):322-8. Epub 2007 Jun 1. doi: 10.1016/j.jaci.2007.04.022.

Yao H, Edirisinghe I, Yang SR, et al. Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice. Am J Pathol. 2008 May;172(5):1222-37. doi: 10.2353/ajpath.2008.070765. Epub 2008 Apr 10.

Juul K, Tybjaerg-Hansen A, Marklund S, Lange P, Nordestgaard BG. Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006 Apr 15;173(8):858-64. Epub 2006 Jan 6. doi: 10.1164/rccm.200509-1387OC.

Fitzpatrick AM, Teague WG, Burwell L, Brown MS, Brown LA; NIH/NHLBI Severe Asthma Research Program. Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma. Pediatr Res. 2011 Feb;69(2):154-9. doi: 10.1203/PDR.0b013e3182026370.

Koike Y, Hisada T, Utsugi M, et al. Glutathione redox regulates airway hyperresponsiveness and airway inflammation in mice. Am J Respir Cell Mol Biol. 2007 Sep;37(3):322-9. Epub 2007 May 16. doi: 10.1165/rcmb.2006-0423OC.

Gu ML, Zhao J. Mapping and localization of susceptible genes in asthma. Chin Med J (Engl). 2011 Jan;124(1):132-43. PMID: 21362321.

Kwon HS, Bae YJ, Moon KA, et al. Hyperoxidized peroxiredoxins in peripheral blood mononuclear cells of asthma patients is associated with asthma severity. Life Sci. 2012 Apr 9;90(13-14):502-8. doi: 10.1016/j.lfs.2012.01.003. Epub 2012 Jan 20.

Tubby C, Harrison T, Todd I, Fairclough L. Immunological basis of reversible and fixed airways disease. Clin Sci (Lond). 2011 Oct;121(7):285-96. doi: 10.1042/CS20110062.

Sutcliffe A, Hollins F, Gomez E, et al. Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsicairway smooth muscle hypercontractility in asthma. Am J Respir Crit Care Med. 2012 Feb 1;185(3):267-74. doi: 10.1164/rccm.201107-1281OC. Epub 2011 Nov 22.

DeMeo DL, Mariani T, Bhattacharya S, et al. Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet. 2009 Oct;85(4):493-502. doi: 10.1016/j.ajhg.2009.09.004.

Lee IT, Yang CM. Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases. Biochem Pharmacol. 2012 Sep 1;84(5):581-90. doi: 10.1016/j.bcp.2012.05.005. Epub 2012 May 12.

Gould NS, Min E, Gauthier S, Martin RJ, Day BJ. Lung glutathione adaptive responses to cigarette smoke exposure. Respir Res. 2011 Oct 7;12:133. doi: 10.1186/1465-9921-12-133.

MacNee W. Oxidants and COPD. Curr Drug Targets Inflamm Allergy. 2005 Dec;4(6):627-41. PMID: 17305519.

Meyer HA, Dittrich AM, Hamelmann E. Different isoforms of glutathione peroxidase cause opposing effects during the development of allergic asthma in mice. Antioxid Redox Signal. 2011 Jan 1;14(1):169-70; author reply 170-1. doi: 10.1089/ars.2010.3591. Epub 2010 Nov 5.

Misso NL, Thompson PJ. Oxidative stress and antioxidant deficiencies in asthma: potential modification by diet. Redox Rep. 2005;10(5):247-55. doi: 10.1179/135100005X70233.

Mistry D, Stockley RA. Gamma-glutamyl transferase: the silent partner? COPD. 2010 Aug;7(4):285-90. doi: 10.3109/15412555.2010.496819.

Maes T, Provoost S, Lanckacker EA, et al. Mouse models to unravel the role of inhaled pollutants on allergic sensitization and airway inflammation. Respir Res. 2010 Jan 21;11:7. doi: 10.1186/1465-9921-11-7.

Nakamura H. Genetics of COPD. Allergol Int. 2011 Sep;60(3):253-8. doi: 10.2332/allergolint.11-RAI-0326.

Ghosh S, Janocha AJ, Aronica MA, et al. Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation. J Immunol. 2006 May 1;176(9):5587-97. PMID: 16622028.

Dweik RA, Comhair SA, Gaston B, et al. NO chemical events in the human airway during the immediate and late antigen-induced asthmatic response. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2622-7. Epub 2001 Feb 20. doi: 10.1073/pnas.051629498.

Sturrock A, Huecksteadt TP, Norman K, et al. Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1543-55. Epub 2007 Mar 16. doi: 10.1152/ajplung.00430.2006.

Guo CH , Liu PJ, Lin KP, Chen PC. Nutritional supplement therapy improves oxidative stress, immune response, pulmonary function, and quality of life in allergic asthma patients: an open-label pilot study. Altern Med Rev. 2012 Mar;17(1):42-56. PMID: 22502622.

Di Stefano A, Gnemmi I, Vicari C, Balbi B. Oxidant-antioxidant balance in asthma and the potential of antioxidant therapies. Monaldi Arch Chest Dis. 2010 Sep;73(3):96-8. doi:10.4081/monaldi.2010.292.

Rahman I, Gilmour PS, Jimenez LA, MacNee W. Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. Mol Cell Biochem. 2002 May-Jun;234-235(1-2):239-48. PMID: 12162440.

Islam T, McConnell R, Gauderman WJ, Avol E, Peters JM, Gilliland FD. Ozone, oxidant defense genes, and risk of asthma during adolescence. Am J Respir Crit Care Med. 2008 Feb 15;177(4):388-95. Epub 2007 Nov 29. doi: 10.1164/rccm.200706-863OC.

Inoue K, Takano H, Koike E, et al. Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthma. Int Immunopharmacol. 2009 Oct;9(11):1281-8. doi: 10.1016/j.intimp.2009.07.010. Epub 2009 Aug 5.

Boutten A, Goven D, Artaud-Macari E, Bonay M. Protective role of Nrf2 in the lungs against oxidative airway diseases. Med Sci (Paris). 2011 Nov;27(11):966-72. doi: 10.1051/medsci/20112711012. Epub 2011 Nov 30. (in French).

Que LG, Liu L, Yan Y, et al. Protection from experimental asthma by an endogenous bronchodilator. Science. 2005 Jun 10;308(5728):1618-21. Epub 2005 May 26. doi: 10.1126/science.1108228.

Rahman I, Adcock IM. Oxidative stress and redox regulation of lung inflammation in COPD. Eur Respir J. 2006 Jul;28(1):219-42. doi: 10.1183/09031936.06.00053805.

Crawford A, Fassett RG, Geraghty DP, et al. Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease. Gene. 2012 Jun 15;501(2):89-103. doi: 10.1016/j.gene.2012.04.011. Epub 2012 Apr 14.

Reynaert NL. Glutathione biochemistry in asthma. Biochim Biophys Acta. 2011 Nov;1810(11):1045-51. doi: 10.1016/j.bbagen.2011.01.010. Epub 2011 Jan 31.

Riedl MA, Nel AE. Importance of oxidative stress in the pathogenesis and treatment of asthma. Curr Opin Allergy Clin Immunol. 2008 Feb;8(1):49-56. doi: 10.1097/ACI.0b013e3282f3d913.

Llinàs L, Peinado VI, Ramon Goñi J, et al. Similar gene expression profiles in smokers and patients with moderate COPD. Pulm Pharmacol Ther. 2011 Feb;24(1):32-41. doi: 10.1016/j.pupt.2010.10.010. Epub 2010 Oct 21.

Que LG, Yang Z, Stamler JS, Lugogo NL, Kraft M. S-nitrosoglutathione reductase: an important regulator in human asthma. Am J Respir Crit Care Med. 2009 Aug 1;180(3):226-31. doi: 10.1164/rccm.200901-0158OC. Epub 2009 Apr 24.

Sugiura H, Ichinose M. Oxidative and nitrative stress in bronchial asthma. Antioxid Redox Signal. 2008 Apr;10(4):785-97. doi: 10.1089/ars.2007.1937.

Dahl M, Bowler RP, Juul K, Crapo JD, Levy S, Nordestgaard BG. Superoxide dismutase 3 polymorphism associated with reduced lung function in two large populations. Am J Respir Crit Care Med. 2008 Nov 1;178(9):906-12. doi: 10.1164/rccm.200804-549OC. Epub 2008 Aug 14.

Yang LL, Huang MS, Huang CC, et al. The association between adult asthma and superoxide dismutase and catalase gene activity. Int Arch Allergy Immunol. 2011;156(4):373-80. doi: 10.1159/000324448. Epub 2011 Aug 9.

Tanaka K, Tanaka Y, Miyazaki Y, et al. Therapeutic effect of lecithinized superoxide dismutase on pulmonary emphysema. J Pharmacol Exp Ther. 2011 Sep;338(3):810-8. doi: 10.1124/jpet.111.179051. Epub 2011 Jun 10.

Torii M, Wang L, Ma N, et al. Thioredoxin suppresses airway inflammation independently of systemic Th1/Th2 immune modulation. Eur J Immunol. 2010 Mar;40(3):787-96. doi: 10.1002/eji.200939724.

Ichiki H, Hoshino T, Kinoshita T, et al. Thioredoxin suppresses airway hyperresponsiveness and airway inflammation in asthma. Biochem Biophys Res Commun. 2005 Sep 9;334(4):1141-8. doi: 10.1016/j.bbrc.2005.07.007.

Ito W, Kobayashi N, Takeda M, et al. Thioredoxin in allergic inflammation. Int Arch Allergy Immunol. 2011;155 Suppl 1:142-6. doi: 10.1159/000327501. Epub 2011 Jun 1.

Wedes SH, Wu W, Comhair SA, et al. Urinary bromotyrosine measures asthma control and predicts asthma exacerbations in children. J Pediatr. 2011 Aug;159(2):248-55.e1. doi: 10.1016/j.jpeds.2011.01.029. Epub 2011 Mar 10.

Yao H, Rahman I. Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol Appl Pharmacol. 2011 Jul 15;254(2):72-85. doi: 10.1016/j.taap.2009.10.022. Epub 2011 Feb 4.

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