Serum eotaxin level as a marker of atopic dermatitis severity in infants

V.A. Klymenko, O.M. Ashcheulov, O.V. Vуsotska, G.I. Pecherskaya


Background. Atopic dermatitis (AD) is a chronic inflammatory disease of the skin. The allergic skin inflammation is the heart of the clinical manifestation of AD. Eosinophils are one of the most significant effector cells of allergic inflammation. However, blood eosinophilia occurs only in some children with AD. In clinical practice at the present time, the activity of allergic inflammation is evaluated not only by the level of eosinophils, but also by concentrations of cytokines, one of which is eotaxin. The objective of the scientific work was to determine the role of eotaxin in the pathogenesis of AD. Materials and methods. The study involved 60 children aged 60 days to 3 years with clinical manifestations of AD during disease exacerbation (main group) and 36 healthy children (control group). Results. The median and interquartile intervals of serum eotaxin levels were established in mild (32.10 [16.05–41.86] pg/ml), moderate (33.5 [27.9–80.94] pg/ml) and severe (25.11 [18.14–54.42] pg/ml) AD. There were not found significant differences between groups and reference values of the control group (46.05 [27.9–61.4] pg/ml). There were isolated groups of patients with high (18 children — 50.2–189.78 pg/ml) and low (16 children — 2.79–19.54 pg/ml) eotaxin levels. The correlation was established between eotaxin levels and clinical features of AD: the total score on the SCORAD (Severity scoring of atopic dermatitis) scale (p = 0.01), the prevalence (p = 0.09), the total intensity of morphological manifestations (p = 0.01), redness (p = 0.01), lichenification (p = 0.01), swelling/papule (p = 0.06), oozing/crusting (p = 0.06), excoriation (p = 0.01), itching (p = 0.01) and sleep disorders (p = 0.01). It was found a possible increase in the number of CD3, CD4, CD8, CD16, CD22, CD25 lymphocytes, IgG and total IgE in the group of children with high eotaxin levels as compared to the patients with low eotaxin levels. Conclusions. Eotaxin is involved in the development of the AD acute phase and can be used as an objective severity marker of exacerbation.


eotaxin; atopic dermatitis; infants


Nutten S. Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab. 2015;66 Suppl 1:8-16. doi: 10.1159/000370220.

Pols DH, Wartna JB, Moed H, van Alphen EI, Bohnen AM, Bindels PJ. Atopic dermatitis, asthma and allergic rhinitis in general practice and the open population: a systematic review. Scand J Prim Health Care. 2016 Jun;34(2):143-50. doi: 10.3109/02813432.2016.1160629.

Leung DY, Guttman-Yassky E. Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches. J Allergy Clin Immunol. 2014 Oct;134(4):769-79. doi: 10.1016/j.jaci.2014.08.008.

Griffiths CE, van de Kerkhof P, Czarnecka-Operacz M. Psoriasis and Atopic Dermatitis. Dermatol Ther (Heidelb). 2017 Jan;7(Suppl 1):31-41. doi: 10.1007/s13555-016-0167-9.

Litus VI, Kuznecova LV, Babadzhan VD, Osipova LS, Kuznecov OG. Evaluation of the effect of antihistamines on the use of an adaptol for the treatment of patients with allergic dermatitis. Kyiv: Ministry of Health of Ukraine; 2017. 35 p.

Foster E. Eosinphils increase sensory neuron branching. Scholar Archive Oregon Health & Science University; 2010. 624 p. doi: 10.6083/M4C53HVH.

Wu Z, Zhong J, Su C, Huang Y, Huang T, Xu Z. Eosinophilia triggers changes in IL-5, eotaxin and IL-17, and acts as a prognostic biomarker for atopic dermatitis. Tropical Journal of Pharmaceutical Research. 2017;16(5):1167-72. doi: 10.4314/tjpr.v16i5.26.

Amerio P, Frezzolini A, Feliciani C, et al. Eotaxins and CCR3 receptor in inflammatory and allergic skin diseases: therapeutical implications. Curr Drug Targets Inflamm Allergy. 2003 Mar;2(1):81-94. doi: 10.2174/1568010033344480.

Yanagisawa R, Takano H, Inoue K, Koike E, Sadakane K, Ichinose T. Effects of maternal exposure to di-(2-ethylhexyl) phthalate during fetal and/or neonatal periods on atopic dermatitis in male offspring. Environ Health Perspect. 2008 Sep;116(9):1136-41. doi: 10.1289/ehp.11191.

Kuo NW, Gao YG, Schill MS, Isern N, Dupureur CM, Liwang PJ. Structural insights into the interaction between a potent anti-inflammatory protein, viral CC chemokine inhibitor (vCCI), and the human CC chemokine, Eotaxin-1. J Biol Chem. 2014 Mar 7;289(10):6592-603. doi: 10.1074/jbc.M113.538991.

Nino G, Huseni S, Perez GF, et al. Directional secretory response of double stranded RNA-induced thymic stromal lymphopoetin (TSLP) and CCL11/eotaxin-1 in human asthmatic airways. PLoS One. 2014 Dec 29;9(12):e115398. doi: 10.1371/journal.pone.0115398. eCollection 2014.

Falk MK, Singh A, Faber C, Nissen MH, Hviid T, Sørensen TL. Blood expression levels of chemokine receptor CCR3 and chemokine CCL11 in age-related macular degeneration: a case–control study. BMC Ophthalmol. 2014 Feb 27;14:22. doi: 10.1186/1471-2415-14-22.

Ahmadi Z, Hassanshahi G, Khorramdelazad H, Zainodini N, Koochakzadeh L. An overlook to the characteristics and roles played by eotaxin network in the pathophysiology of food allergies: allergic asthma and atopic dermatitis. Inflammation. 2016 Jun;39(3):1253-67. doi: 10.1007/s10753-016-0303-9.

Yawalkar N, Uguccioni M, Schärer J, et al. Enhanced expression of eotaxin and CCR3 in atopic dermatitis. Journal of Investigative J Invest Dermatol. 1999 Jul;113(1):43-8. doi: 10.1046/j.1523-1747.1999.00619.x.

Nedoszytko B, Sokołowska-Wojdyło M, Ruckemann-Dziurdzińska K, Roszkiewicz J, Nowicki RJ. Chemokines and cytokines network in the pathogenesis of the inflammatory skin diseases: atopic dermatitis, psoriasis and skin mastocytosis. Postepy Dermatol Alergol. 2014 May;31(2):84-91. doi: 10.5114/pdia.2014.40920.

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