Effectiveness of probiotic therapy for gastrointestinal forms of food allergy in children

O.M. Okhotnikova, Yu.R. Chernysh


Background. Intestinal microbiota is involved in the development of oral tolerance. Therefore, there is interest in using probiotics that will contribute to colonization of the intestine, as well as to the development of intestinal homeostasis. There is also a need for studies on the effectiveness of probiotics for the prevention and treatment of allergic diseases in children. The purpose of the study was to evaluate the effectiveness of using biopreparation created on the basis of the spore-forming microorganism Bacillus subtilis in the comprehensive therapy of children with gastrointestinal symptoms of food allergy. Materials and methods. We examined 34 children aged 3.5 to 12 years with food allergies with gastrointestinal complaints. The main group included 18 children, the comparison group consisted of 16 patients. Children of the main group in addition to basic therapy received probiotic on the basis of Bacillus subtilis (1 dose 2 times a day for 20 days). The effectiveness of therapy was assessed by the rate and completeness of reduction of gastrointestinal symptoms and manifestations of comorbid allergic pathology. Results. In patients of the main group, the reduction of gastrointestinal symptoms and symptoms of comorbid allergic pathology was faster. A gradual decrease in the level of specific IgE to food and inhalant allergens by 25–30 % was noted after 10 days of using comprehensive treatment, and by 35–40 % — in 21 days after taking the probiotic based on Bacillus subtilis. All children had changes in the bacteriological examination of the stool (the lack of bifido- and lactobacilli, an increase in the number and changes in the species ratio of the opportunistic flora). Normalization of the intestinal microbiocenosis was noted in 78 % of cases after repeated bacteriological study of stool in children of the main group. After taking the probiotic based on Bacillus subtilis, there were no complications or side effects in all patients, while episodes of abdominal pain and stool disorders were observed in children of the comparison group. There was a moderate improvement in the clinical symptoms of comorbid allergic pathology (allergic rhinitis, atopic dermatitis, bronchial asthma) during the 3-week course of using probiotic on the basis of Bacillus subtilis. Conclusions. The administration of the probiotic based on Bacillus subtilis in the comprehensive therapy of children with gastrointestinal form of food allergy promotes rapid regression of gastrointestinal manifestations and improves general condition of patients.


children; Bacillus subtilis; gastrointestinal food ­allergy


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