Role of the mechanisms of the antioxidant system in the development of respiratory diseases

A.E. Abaturov, A.P. Volosovets, T.P. Borysova


The review of the literature presents current data on the role of NOX proteins in the physiology of the lungs and in the development of respiratory diseases. The value of the transcription factor NRF2, superoxide dismutase, catalase, glutathione system, glutaredoxin, thioredoxin, peroxiredoxin in the development of respiratory diseases was shown. Hereditary di­seases associated with generators of activated oxygen-contai-ning metabolites and components of the antioxidant system are presented. The main markers of oxidative stress and the process of inflammation in the respiratory tract are described.


diseases of the respiratory system; antioxidant system; review


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