About the role of Ureaplasma and Mycoplasma infection in the development of bronchopulmonary dysplasia in infants

S.I. Ilchenko, A.A. Fialkovskaya, S.G. Ivanus

Abstract


The article describes literature data and own observation of ureacoplasmic infection as the cause of the development of bronchopulmonary dysplasia (BPD) in infants. Bronchopulmonary dysplasia as a pathology that occurs in newborn children after resuscitation, in particular oxygen therapy or mechanical ventilation is actively studied by pathomorphologists and clinicians. The questions about the role of infections in the development of BPD in both premature and term infants remain relevant and underinvestigated today. Numerous studies have shown that colonization of the respiratory tract of newborn organisms such as Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, Cytomegalovirus, is associated with a high risk of developing BPD compared with uninfected children. Ureaplasma urealyticum are the most common microbes found in the infected amniotic fluid, placenta and respiratory tract of newborns, and their ability to cause inflammation in these areas is undeniable. Bronchopulmonary dysplasia associated with these microorganisms is not necessarily directly connected with bacteria, and most likely develops due to their potential to stimulate proinflammatory cytokines (TNF, IL-1 and IL-8) or possible blocking of cytokines (IL-6 and IL-10). The described case illustrates the role of these microorganisms in the development of severe pneumonia outcome in BPD in a term child. A feature of the case is that with proper medical tactics in relation to infected pregnant and as soon as possible early prevention of the development of infection of the newborn, the development of severe, irreversible changes in his lungs could have been avoided.

Keywords


bronchopulmonary dysplasia; Ureaplasma urealyticum; Mycoplasma hominis; newborns

References


Duka KD, Іl'chenko SІ, Duka ІG. Modern aspects of chronic bronchial inflammation in childhood and ways to prevent. Sovremennaja pediatrija. 2012;3(43):69-71. (In Ukrainian).

Trountsova ES, Sagitova GR, Khasyanov EA. Problems of chronic brochopulmonary diseases in adolescents. Vestnik sovremennoj klinicheskoj mediciny. 2009;3:37-9. (In Russian).

Skachkova MA, Nikitina OV, Chainikova IN, Karpova EG, Abubakirova AV, Tarasenko NF. Smoking as risk factor for development diseasesof the respiratory tract in children and teenagers. Orenburgskij medicinskij vestnik. 2015;2(10):35-8. (In Russian).

Antonov NS, Sakharova GM, Mokina NA, Saraeva NI, Donitova VV. A comparative analysis of risk factors of respiratory disorders in adolescents. Russian Pulmonology. 2011;(4):44-8. doi: 10.18093/0869-0189-2011-0-4-44-48. (In Russian).

Bataev K, Dadaev M. Chronic obstructive bronchitis: pathogenesis, development factors, pharmacotherapy. Vrach. 2013;1:22-4. (In Russian).

Dolinchuk LV, Basanets AV, Andrushchenko TA. Genetic aspects of chronic obstructive pulmonary disease development. Ukraїns'kii zhurnal z problem meditsini pratsі. 2013;1(34):44-56. (Іn Ukrainian).

Іlchenko SІ. Forecasting the development of chronic bronchitis in children and adolescents by the method of logistic regression. Zdorov’ye Rebenka. 2010;6(27):28-31. (In Ukrainian).

Zakharova IA. Prognosis of chronic bronchitis development in young adults. Sibirskoe medicinskoe obrazovanie.2014;6:79-82. (In Russian).

Dzyubaylo AV. Prognostication of chronic obstructive pulmonary disease by the indices of external respiration function. Kazanskiy meditsinskiy zhurnal. 2010;5:609-10. (In Russian).

Soloviev KI. Active case finding of chronic nonspecific lung diseases by screening. Vestnik sovremennoj klinicheskoj mediciny. 2012;2:30-4. (In Russian).




DOI: https://doi.org/10.22141/2224-0551.12.4.2017.107635

Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 CHILD`S HEALTH

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru