Molecular-genetic concept of the formation of psychological type in children with obesity associated with lactose intolerance
Background. The purpose of the study was to determine the association of single-nucleotide polymorphisms (SNP) in the lactase gene (LCT) with the development of obesity in children based on the study of personal and reactive anxiety (Spielberger-Khanin test) and quality of life assessment (MOS SF-36). Materials and methods. Genotyping was performed on a polymorphic enhancer of the gene MCM6 (minichromosome maintenance complex complex 6) encoding the expression of the LCT gene in 62 children aged 12–18 years with different forms of obesity. The first group (n = 31) included children with recessive allele C/C 13910 polymorphism rs4988234. The second group (n = 31) consisted of children with dominant homozygous allele T/T 13910 or heterozygous allele C/T 13910. Results. There was a 6-fold increase in the incidence of the C/C 13910 genotype in children with severe obesity (body mass index (BMI) > 97th percentile). The presence of a high level of personality (46.5 ± 0.4) and an average level of reactive anxiety (33.2 ± 0.9) in children with genotype C/C 13910 was proved, as compared to a moderately high level of personality (37.5 ± 0.8) and low reactive anxiety (24.3 ± 0.8) in patients with genotypes C/T and T/T 13910 (p < 0.05). The results of the quality of life assessment in adolescents with obesity were characterized by a deterioration in the level of the physical component of health in the genotype C/C 13910, namely in young men — due to a decrease in the parameter of a role-related functioning determined by the physical condition, in girls — due to the decrease in the general level of the health (p < 0.05). Conclusions. Thus, the study of single-nucleotide polymorphisms in the LCT gene (rs4988234) revealed associations of the C/C 13910 genotype with severe forms of abdominal obesity in children (BMI > 97th percentile), increased anxiety and decreased quality of life assessment due to the physical component of health, that can be used in the modeling of behavioral intervention and require a possible substitution treatment with exogenous lactase preparations.
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Abaturov OE, Nikulina AO. Association of one-nucleotide polimorphism of the lactase gene with the insulin resistance of children. Suchasnі medichnі tehnologії. 2016;4(31): 33-36. (In Ukrainian).
Zelinska NB, Rudenko NG, Rudenko OG. Statistical-analitichny dovіdnik children's endocrinologist. DZ Center for Statistical Medicine of the Ministry of Health of Ukraine; Kyiv. 2016: 22. (In Ukrainian).
BeLue R, Francis LA, Colaco B. Mental Health Problems and Overweight in a Nationally Representative Sample of Adolescents: Effects of Race and Ethnicity. Pediatrics. 2009 Feb;123(2): 697-702. doi: 10.1542/peds.2008-0687.
Colquitt JL, Loveman E, O'Malley C, et al. Diet, physical activity, and behavioural interventions for the treatment of overweight or obesity in preschool children up to the age of 6 years. Cochrane Database Syst Rev. 2016 Mar 10;3:CD012105. doi: 10.1002/14651858.CD012105.
Gracious BL, Cook SR, Meyer AE, Chirieac MC, Malhi N, Fischetti AT, Finucane TL, Ma Y. Prevalence of overweight and obesity in adolescents with severe mental illness: a cross-sectional chart review. J Clin Psychiatry. 2010 Jul;71(7):949-54. doi: 10.4088/JCP.09m05033gre. Epub 2010 May 4.
Joung KE, Park KH, Zaichenko L, et al. Early life adversity is associated with elevated levels of circulating leptin, irisin, and decreased levels of adiponectin in midlife adults. J Clin Endocrinol Metab. 2014 Jun;99(6):E1055-60. doi: 10.1210/jc.2013-3669.
Knop C, Singer V, Uysal Y, et al. Extremely obese children respond better than extremely obese adolescents to lifestyle interventions. Pediatr Obes. 2015 Feb;10(1):7-14. doi: 10.1111/j.2047-6310.2013.00212.
Martin A, Saunders DH, Shenkin SD et al. Lifestyle intervention for improving school achievement in overweight or obese children and adolescents. Cochrane Database Syst Rev. 2014 Mar 14;(3):CD009728. doi: 10.1002/14651858.CD009728.pub2.
Misselwitz B, Pohl D, Frühauf H, Fried M et al. Lactose malabsorption and intolerance: pathogenesis, diagnosis and treatment. United European Gastroenterol. J. 2013; 1(3):151-159. doi: 10.1177/2050640613484463.
Nascimento MM, Melo TR, Pinto RM, et al. Parents' perception of health-related quality of life in children and adolescents with excess weight. J Pediatr (Rio J). 2016 Jan-Feb;92(1):65-72. doi: 10.1016/j.jped.2015.04.006. Epub 2015 Sep 21.
Paasela M, K.-L. Kolho, O. Vaarala, et al. Lactose inhibits regulatory T-cell-mediated suppression of effector T-cell interferon-γ and IL-17 production. British Journal of Nutrients. 2014;112(11):1819-25. doi: 10.1017/S0007114514001998.
Peplies J, Börnhorst C, Günther K et al. IDEFICS consortium. Longitudinal associations of lifestyle factors and weight status with insulin resistance (HOMA-IR) in preadolescent children: the large prospective cohort study IDEFICS. Int J Behav Nutr Phys Act. 2016 Sep 2;13(1): 97. doi: 10.1186/s12966-016-0424-4.
Rajjo T, Mohammed K, Alsawas M, Ahmed AT, Farah W, Asi N, Almasri J, Prokop LJ, Murad MH. Treatment of Pediatric Obesity: An Umbrella Systematic Review. J Clin Endocrinol Metab. 2017 Mar 1;102(3):763-75. doi: 10.1210/jc.2016-2574.
Savaiano DA, Ritter AJ, Klaenhammer TR, James GM еt al Improving lactose digestion and symptoms of lactose intolerance with a novel galacto-oligosaccharide (RP-G28): a randomized, double-blind clinical trial. Nutr J. 2013;12:160. doi: 10.1186/1475-2891-12-160
Soriа С. Milk Consumption Per Capita Worldwide. Food Beast: Map of Milk Consumption and Lactose Intolerance Around the World. 2015 Dec 29; 12:345-364. available from: http://www.indexmundi.com/blog/index.php/2013/03/01/milk-consumption-per-capita-worldwide/
Vondrova D, Kapsdorfer D, Argalasova L, et al. The impact of selected environmental, behavioral and psychosocial factors on schoolchildren's somatic and mental health. Rev Environ Health. 2016 Nov 22. doi: 10.1515/reveh-2016-0034.
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