Abdominal fat index — a non-invasive marker of hepatic steatosis and insulin resistance in children
AFI was significantly higher in persons with hepatic steatosis, as compared to children with normal weight and obese children (0.49 ± 0.24 — in group 1, 0.30 ± 0.10 — in group 2 and 0.24 ± 0.08 — in group 3; p < 0.05). The level of HOMA index in children of group 1 was 1.7 times higher than that of in group 2 (p < 0.05). Providing correlation analysis, we revealed that AFI had a positive correlation with the level of HOMA index (r = 0.540. p < 0.05) and a positive correlation with C-peptide levels (r = 0.99, p < 0.05). C-peptide level was associated with growth of the VF/SF ratio (r = 0.78, p < 0.05) and showed a negative correlation with the thickness of subcutaneous fat (r = 0.42, p < 0.05). Conclusion. Our study showed that abdominal fat index characterizes the distribution of adipose tissue in children and can be used as a non-invasive marker of steatohepatosis and insulin resistance. It was determined that AFI level above 0.35 with sensitivity of 88.9 % indicates the presence of hepatic steatosis in children.
Full Text:PDF (Українська)
Park BJ, Kim YJ, Kim DH, Kim W, Jung YJ, Yoon JH, et al. Visceral adipose tissue area is an independent risk factor for hepatic steatosis. J Gastroenterol Hepatol. 2008 Jun;23(6):900-7. doi: 10.1111/j.1440-1746.2007.05212.x.
World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO consultation on obesity. World Health Organization: Geneva, 1998. Available from: http://www.who.int/nutrition/publications/obesity/WHO_TRS_894/en/
Jung JH, Jung MK, Kim KE, Kwon AR, Chae HW, Yoon CS. Ultrasound measurement of pediatric visceral fat thickness: correlations with metabolic and liver profiles. Annals of Pediatric Endocrinology & Metabolism. 2016; 21(2): 75-80. doi: 10.6065/apem.2016.21.2.75.
Stepanov YM, Abaturov OE, Zavgorodnyaya NY, Skyrda IY. Non-alcoholic fatty liver disease in children: current view on diagnostics and treatment (Part I). Hastroenterolohiya. 2015;2(56):99-107. doi: 10.22141/2308-2097.2.56.2015.81504.
Meigs JB, Wilson PWF, Fox CS, Vasan RS, Nathan DM, et al. Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. Journal of Clinical Endocrinology and Metabolism. 2006;91(8):2906-12. doi: 10.1210/jc.2006-0594.
Armellini F, Zamboni M, Rigo L, Todesco T, Bergamo-Andreis IA, Procacci C, Bosello O. The contribution of sonography to the measurement of intra-abdominal fat. J Clin Ultrasound. 1990;18:563-7. PMID: 2170455.
Fernando F. Ribeiro Filho, Lydia S. Mariosa; Sandra RG. Ferreira; Maria Teresa Zanella. Visceral fat and metabolic syndrome: more than a simple association. Arquivos Brasileiros de Endocrinologia & Metabologia. 2006;50(2):230-8. doi.org/10.1590/S0004-27302006000200009.
Sung Hyun Lee, Dongwan Kim, Min Young Baek, Hann Tchah, Yeon Sun Kim, Eell Ryoo, et al. Abdominal Subcutaneous Fat Thickness Measured by Ultrasonography Correlates with Hyperlipidemia and Steatohepatitis in Obese. Pediatric gastroenterology, hepatology & nutrition. 2015;18(2):108-14. doi: 10.5223%2Fpghn.2015.18.2.108.
Kim D, Chung GE, Kwak MS. Body fat distribution and risk of incident and regressed nonalcoholic fatty liver disease. Clinical Gastroenterology and Hepatology. 2016;14(1):132-8. doi: 10.1016/j.cgh.2015.07.024.
Kim JY, Tfayli H, Michaliszyn SF. Distinguishing characteristics of metabolically healthy versus metabolically unhealthy obese adolescent girls with polycystic ovary syndrome. Fertility and sterility. 2016;105(6):1603-11. doi: 10.1016/j.fertnstert.2016.02.004.
Fukuda K, Seki Y, Ichihi M, Okada T, Hirata A, Kogita S, et al. Usefulness of ultrasonographic estimation of preperitoneal and subcutaneous fat thickness in the diagnosis of nonalcoholic fatty liver disease in diabetic patients. Journal of Medical Ultrasonics. 2015;42(3):357-63. doi: 10.1007/s10396-015-0615-7.
Suzuki R, Watanabe S, Hirai Y, Akiyama K, Nishide T, Matsushima Y, et al. Abdominal wall fat index, estimated by ultrasonography, for assessment of the ratio of visceral fat to subcutaneous fat in the abdomen. The American journal of medicine. 1993;95(3):309-14. PMID: 8368228.
Telma Sakuno, Letícia Mary Tomita, Carolina Mywa Tomita, Isabela de Carlos Back Giuliano, Amanda Ibagy, Nilza Maria Medeiros Perin, et al. Sonographic evaluation of visceral and subcutaneous fat in obese children. Radiologia brasileira: 2014;47(3):149-53. doi: 10.1590%2F0100-3984.2013.1828.
- There are currently no refbacks.
Copyright (c) 2017 CHILD`S HEALTH
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Publishing House Zaslavsky, 1997-2018