Abdominal fat index — a non-invasive marker of hepatic steatosis and insulin resistance in children
AFI was significantly higher in persons with hepatic steatosis, as compared to children with normal weight and obese children (0.49 ± 0.24 — in group 1, 0.30 ± 0.10 — in group 2 and 0.24 ± 0.08 — in group 3; p < 0.05). The level of HOMA index in children of group 1 was 1.7 times higher than that of in group 2 (p < 0.05). Providing correlation analysis, we revealed that AFI had a positive correlation with the level of HOMA index (r = 0.540. p < 0.05) and a positive correlation with C-peptide levels (r = 0.99, p < 0.05). C-peptide level was associated with growth of the VF/SF ratio (r = 0.78, p < 0.05) and showed a negative correlation with the thickness of subcutaneous fat (r = 0.42, p < 0.05). Conclusion. Our study showed that abdominal fat index characterizes the distribution of adipose tissue in children and can be used as a non-invasive marker of steatohepatosis and insulin resistance. It was determined that AFI level above 0.35 with sensitivity of 88.9 % indicates the presence of hepatic steatosis in children.
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