Improvement of therapy for escherichiosis in children infected with Epstein-Barr virus

Ye.S. Olkhovskyy, S.V. Kuznetsov


Background. Escherichiosis remains one of the most common intestinal infections, especially among young children. Indigestion of essential nutrients, transient fermentopathy, imbalance of the symbiotic flora, which develop in escherichiosis in combination with general intoxication and water-electrolyte disturbances, can lead to unfavorable outcomes. One of the factors influencing the course of escherichiosis can be Epstein-Barr virus (EBV) infection in the child. Purpose of the research — improvement of treatment of children with escherichiosis and EBV infection in different periods of the disease. Materials and methods. We examined 74 children aged 2–3 years, who were treated at the Regional Children’s Clinical Infectious Diseases Hospital in Kharkiv with a diagnosis of moderate-to-severe escherichiosis. A group of 36 children was selected, who received conventional therapy with early gradual restoration of nutrition according to the existing protocol, and the restoration of the qualitative and quantitative composition of food was carried out as soon as possible (first group). The second group was represented by 38 children, who received two-day prolonged gradual restoration of the diet: more gradual increasing the volume of food at each feeding and reducing the number of feedings per day. Children of the second group received drugs containing Lactobacillus, milk thistle extract and B vitamins (once daily with meals) from the first day. Ultrasound examination of the abdominal cavity was performed in all children. Results. Analysis of the main clinical, laboratory and instrumental parameters of patients in both groups during their stay in the hospital and one month after the discharge from the hospital revealed that in children of the second group, in whom rational diet therapy was applied, there was a reduction in the duration of bowel dysfunction, abdominal syndrome, flatulence; the parameters of the coprological test and the echosonoscopy of the hepatic parenchyma were normalized more quickly. Patients on the optimal diet regained their weight in a shorter period. The proposed methods of improving the therapy made it possible to prevent exacerbation of escherichiosis in children of the second group at the early convalescence stages. Conclusions. Early detection of EBV infection in children with escherichiosis, correction of therapy enable early restoration of physiological processes in the intestine and bile system, normalization of digestion and absorption of nutrients, and generally has a positive effect on the course of the underlying disease.


escherichiosis; Epstein-Barr virus; children; therapy

Full Text:



Malish NG, Chemich OM, Gurіna SV. Epidemiological and clinical features of diarrhea of Escherichiosis nowadays. J Clin Exp Med Res. 2015;3(2):317-25. (in Ukrainian).

Alikeeva GK, Jushhuk ND, Safiullina NH, Sundukov AV, Kozhevnikova GM. E. coli infection in the practice of a infectious disease physician. Infekcionnye bolezni: novosti, mnenija, obuchenie. 2013;4:15-22. (In Russian).

Cyrkunov VM, Pron'ko NV, Jakusevich TV. Esherichiosis nowadays. Zdravoohranenie Belorusi. 2012;5:36-41. (In Russian).

Rambaud JC, Buts JP, Corthier G, Flourie B. Gut microflora. Digestive physiology and pathology. Paris: John Libbey Evrotext; 2006. 247 p.

Ohotnikova EN, Tkacheva TN. Microbiocenosis of the intestine: basic concepts, disorders and their correction. Mistectvo lіkuvannja. 2010;8:34-40. (In Russian).

Shherbinina MB. Indigestion in the aspect of motor disorders and microflora of the digestive tract. Novosti mediciny i farmacii. 2013;13(464):6-7. (In Russian).

Gonchar NV, Nyrkova OI. The role of acute intestinal infections of various etiologies in the origin of irritable bowel syndrome in children. Voprosy detskoj dietologii. 2015;1(13):21-7. (In Russian).

Kramarev SA, Vygovskaya OV. Epstein — Barr virus infection in children. Aktual'naja infektologija. 2013;1:73-8. (In Russian). doi: 10.22141/2312-413x.1.01.2013.82612.

Kucherenko NP, Medvedeva VV, Tychinskaya TL. Features of the clinical course of infectious mononucleosis in children at the modern stage. Mediko-socіal'nі problemi sіm'ї. 2012;3-4(17):102-4. (In Russian).

Bergqvist P, Stennson A, Lycke NY, Bemark M. T cell independent IgA class switch recombination is restricted to the GALT and occurs prior to manifest germinal center formation. J Immunol. 2010 Apr;184(7):3545-53. PMID: 20207993. doi: 10.4049/jimmunol.0901895.

Severson KM, Mallozzi M, Driks A, Knight KL. B cell development in GALT: role of bacterial superantigen-like molecules. J Immunol. 2010;184(12):67-82. PMID: 20483765. doi: 10.4049/jimmunol.1000155.

Sampson H, Aceves S, Bock A et al. Food allergy: A practice parameter update-2014. J Allergy Clin Immunol. 2014;134(5):1016-25.e43. doi: 10.1016/j.jaci.2014.05.013.

Markova DO, Revnova MO, Gurina OP, Nasyrov RA. Clinical and endoscopic and immunohistochemical examination in the diagnosis and characteristics features of lesions of gastrointestinal tract in children with food allergy. Voprosy detskoj dietologii. 2015;13(5):5-12. (In Russian).

Tkach SM, Sizenko AK. Malabsorption syndrome: a new classification, the main causes and mechanisms of development. Suchasna gastroenterologіja. 2012;3(65):114-121. (In Russian).

Kotlova VB, Kokoreva SP, Trushkina AV. Optimization of treatment of Epstein-Barr virus infectious mononucleosis in children. Detskie infekcii. 2015;14(3):43-8. (In Russian). doi: 10.22627/2072-8107-2015-14-3-43-48.

Farthing M, Salam M, Lindberg G, et al. Acute diarrhea in adults and children: a global perspective. World Gastroenterology Organisation. 2012. Available from:

Simovan'jan JeN, Denisenko VB, Grigorjan AV, Kim MA et al. Epstein-Barr virus infection in children: improving the program of diagnosis and treatment. Detskie infekcii. 2016;15(1):15-24. (In Russian). doi: 10.22627/2072-8107-2016-15-1-15-24.

Falagas ME, Tansarli GS, Karageorgopoulos DE, Vardakas KZ. Deaths attributable to carbapenem-resistant Enterobacteriaceae infections. Emerg Infect Dis 2014;20(7):1170-5. doi: 10.3201%2Feid2007.121004.

Falagas ME, Lourida P, Poulikakos P, Rafailidis PI, Tansarli GS. Antibiotic Treatment of Infections Due to Carbapenem-Resistant Enterobacteriaceae: Systematic Evaluation of the Available Evidence. Antimicrob Agents Chemother. 2014;58(2):654-63. doi: 10.1128%2FAAC.01222-13.

Olkhovskyy ES, Kuznecov SV. The course of escherichiosis in children infected by Epstein-Barr virus. In: Proceedings of University Conference of Young Scientists and Students. Kharkiv Jan 20 2016. Kharkiv; 2016. 518 p. (In Ukrainian).

Copyright (c) 2017 CHILD`S HEALTH

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2020


   Seo анализ сайта