Opportunities and prospects in the diagnosis of functional intestinal pathology

A.A. Khanukov, N.S. Fedorova

Abstract


Irritable bowel syndrome (IBS) is the most commonly diagnosed gastrointestinal condition in the 21st century and also the most common cause for referral to gastroenterology clinics. Various mechanisms and theories have been proposed about its etiology, but the biopsychosocial model is the most currently accepted for IBS. The complex of symptoms would be the result of the interaction between psychological, behavioral, psychosocial and environmental factors. The diagnosis of IBS is not confirmed by specific tests. It is made using criteria based on clinical symptoms, such as Rome criteria, unless the symptoms are thought to be atypical. Today, the Rome criteria IV are the most optimal standard for the diagnosis of IBS. At the moment, there are no specific laboratory markers for the diagnosis of IBS. However, a number of different symptoms in IBS patients were demonstrated in recent years, some of which can be used in the future as diagnostic criteria. One of them is the method for the assessment of fecal calprotectin, which demonstrated a high diagnostic value, as a marker of inflammation in differential diagnosis between inflammatory bowel diseases and functional gastrointestinal disorders.

Keywords


irritable bowel syndrome; pathogenesis; biopsychosocial model; Rome criteria; fecal calprotectin

References


Houghton LA, Heitkemper M, Crowell MD, et al. Age, gender and women’s health and patient. Gastroenterology. 2016;150(6):1332-43. doi: 10.1053/j.gastro.2016.02.017.

Camilleri M, Lasch K, Zhou W. Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol. 2012;303:775-85. doi:10.1152/ajpgi.00155.2012.

Parphenov А.I. Enterology on the edge XX and XXI centuries. Rossijskij zhurnal gastrojenterologii gepatologii koloproktologii. 2004;3:41-4. (In Russian).

Jard Knowles B, Douglas A, Drossman DA. Irritable bowel syndrome: diagnosis and treatment. In: Evidence based Gastroenterology and Hepatology. London: BMJ Books; 1999. pp. 241-60.

Baranskaya ЕК. Irritable bowel syndrome: diagnostics and treatment. Consilium Medicum. 2000;2(7). (In Russian).

Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Muller-Lissner SA. Functional bowel disorders and functional abdominal pain. Rome II: A Multinational Consensus Document on Functional Gastrointestinal Disorders. Gut. 1999 Sep;45:1143-7.

Maev IV, Cheremushkin SV. Irritable bowel syndrome. Rome criteria III. Consilium Medicum. Gastroenterology (Comp.). 2007;1:29-33.

Maev IV, Cheremushkin SV. Irritable bowel syndrome. Rome criteria IV. Consilium Medicum. Gastroenterology (Comp.). 2016;8:79-85.

Golisheva SV, Meshalkina IU, Grigoreva GA. Assessment and prognosis of the quality of life of patients with inflammatory bowel disease following long-term follow-up. Gastrojenterologija Sankt- Peterburga. 2005;1(2):32-6. (In Russian).

Stepanov UM, Fedorova NS. The comparative content of fecal calprotectin in patients with chronic inflammatory bowel diseases and functional pathology of the colon. Gastroenterology: interdepartment digest. 2010;44:401-6.




DOI: https://doi.org/10.22141/2224-0551.12.2.1.2017.100995

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