Gastroesophageal reflux disease in pediatric practice: current topical issues

O.Yu. Bielousova, O.L. Slobodianiuk, N.V. Pavlenko, K.V. Voloshyn

Abstract


In recent years, much attention has been paid to the upper digestive tract diseases in children, particularly gastroesophageal reflux disease, as a cause that has an impact on the quality of life, even in children of school age, and thereafter in young adults. Consequently, there are searches for optimization of early detection, new me-thods of non-invasive diagnosis, screening of this pathology in children’s population in order to determine persons with risk factors and to control disease development and complicated course, as well as searches for the formation of preventive activities algorithm. Scientists came to a consensus that all examinations, which are used in pediatric practice, must be maximally available, simple and non-invasive to the extent of child’s condition. The question about advisability of performing esophagogastroduodenoscopy for all patients with complaints of heartburn and with other symptoms of gastroesophageal reflux disease, the question relative to performing ultrasonography of the esophagus in children as an additional method of examination, usage of questionnaire in pediatric practice, formation of disease course prediction algorithm, and identification of preventive measures specific to every patient remain open. In order to explain their application, the developmental mechanisms of this pathology must be well-understood, and individual risk factors that may influence disease severity and disease course prediction, which occur in children in different periods of life, must be taken into account. Therefore, the goal of this research is to provide an overview of modern literature with reference to topical issues of clinical evidence, risk factors, diagnosis, prediction of gastroesophageal reflux disease course in children of different ages (regarding main causative and pathogenic factors, clinical evidence (esophageal and extra-esophageal), diagnostic methods and modern approaches to gastroesophageal reflux disease treatment).

Keywords


gastroesophageal reflux disease; disorders of the motor secretory function; ultrasound diagnosis; non-invasive diagnosis; risk factors; prediction of the disease course

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References


Falk GW. Gastroesophageal Reflux Disease. Gastroenterology Clinics of North America. 2014;43(1):ХІ-ХІІ. doi: 10.1016/j.gtc.2014.01.001.

Gastro-oesophageal reflflux disease: recognition, diagnosis and management in children and young people. NICE guideline. Published: 14 January 2015. https://www.nice.org.uk/guidance/NG1.

Sheptulyn AA. Hastroezofahealnaia refliuksnaia bolezn: spornyie i nereshennyie voprosyi [Gastroesophageal reflux disease: controversial and unresolved issues]. Klynycheskaia medytsyna. 2008;6:8-12. (In Russian).

Boeckxstaens GE, Rohof WO. Pathophysiology of Gastroesophageal Reflux Disease. Gastroenterology Clinics of North America. 2014 Mar;43(1):15-25. doi: 10.1016/j.gtc.2013.11.001.

Pryvorotskyi VF, Luppova NE, Herasymova TA et al. Gastroesophageal reflux disease (GERD) in children. Eksperimental'naja i klinicheskaja gastrojenterologija. 2011; 1:14-21. (In Russian).

Shadrin OH, Ihnatko LV. Current approaches to diagnosis and treatment of gastroesophageal reflux disease in children. Zdorovia Ukrainy, spets. vypusk Hatsroenterolohiia, hematolohiia, koloproktolohiia. 2016;3(41). (In Ukrainian).

Shadrin OH. Vidhuk na dysertatsiinu robotu “Optymizatsiia diahnostyky ta likuvannia hastroezofahealnoi refleksnoi khvoroby u diteу rann'oho viku” [Review on dissertation "Optimization of diagnosis and treatment of gastroesophageal reflux disease in infants]. Kyiv; 2016.

Ronkainen J, Agreus L. Epidemiology of reflux symptoms and GORD. Best Practice & Research Clinical Gastroenterology 2013;27(3):325-37. doi: 10.1016/j.bpg.2013.06.008.

Malfertheiner P, Megraud F, OMorain CA, Atherton J, Axon AT, Bazzoli F, Gensini GF, Gisbert JP, Graham DY, Rokkas T, El-Omar EM, Kuipers EJ. European Helicobacter Study Group. Management of Helicobacter pylori infection – the Maastricht IV/Florence Consensus Report. Gut 2012;61(5):646-64. doi: 10.1136/gutjnl 2012-302084.

El-Serag HB, Sweet S, Winchester CC, Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2014;63(6):871-80. doi: 10.1136/gutjnl-2012-304269.

Fischbach LA, Nordenstedt H, Kramer JR, et al. The association between Barretts esophagus and Helicobacter pylori infection: a meta-analysis. Helicobacter. 2012;17(3):163-75. doi: 10.1111/j.1523-5378.2011.00931.x.

Zhuo X, Zhang Y, Wang Y, et al. Helicobacter pylori infection and oesophageal cancer risk: association studies via evidence-based meta-analyses. Clinical Oncology 2008;20:757-62. doi: 10.1016/j.clon.2008.07.005.

Hunt R, Armstrong D, Katelaris P. World Gastroenterology Organisation Global Guidelines. Global Perspective on Gastroesophageal Reflux Disease. October, 2015. Available from: http://www.worldgastroenterology.org/guidelines/global-guidelines/gastroesophageal-reflux-disease/gastroesophageal-reflux-disease-english

(GERD) Gastroesophageal reflux disease in children. Johns Hopkins Medicine. Available from: http://www.hopkinsmedicine.org/healthlibrary/conditions/pediatrics/gastroesophageal_reflux_disease_gerdheartburn_in_children_90,P01994/. Accessed July 24, 2015.

Lazebnyk LB, Bordyn DS, Masharova AA. Modern understanding of gastroesophageal reflux disease: from Henvalya to Montreal. Eksperimental'naja i klinicheskaja gastrojenterologija. 2007;5:4-10. (In Russian).

Shadrіn OH. Pediatric aspects of gastroesophageal reflux disease. Zdorovia Ukrainy. 2009;6/1:11. (In Russian).

Varil MF, Van Zanten SV, Kahrilas PE, et al. The Montreal definition and classification of gastroesophageal reflux disease: A global evidence based consensus. Am J Gastroenterol. 2006 Aug;101(8):1900-20. doi: 10.1111/j.1572-0241.2006.00630.x.

Zubarenko OV, Kravchenko TYu. The modern view of gastroesophageal reflux disease in children. Perinatologiya i pediatriya. 2013;1(53):114-22. (In Ukrainian).

Boiarska LM, Ivanova KO. About prevalence and manifestation features of gastroesophageal reflux disease in children. Sovremennaia pedyatryia. 2010;2:162-3. (In Ukrainian).

Volosovets OP, Kryvopustov SP, Karulyna YuV. The modern approach to the problem of motor function disorders of the upper digestive tract. Zdorov’e rebenka. 2007;5(114):7-9. (n Ukrainian).

de Bortoli N, Ottonello A, Zerbib F, Sifrim D, Gyawali CP, Savarino E. Between GERD and NERD: the relevance of weakly acidic reflux. Annals of the New York Academy of Sciences. 2016 Sep;1380:218-29. doi: 10.1111/nyas.13169.

Oh TH. Accuracy of the Diagnosis of GORD by Questionnaire, Physicians and a Trial of Proton Pump Inhibitor Treatment: The Diamond Study. J Neurogastroenterol Motil. 2011 1 Jan. 17(1):98-0. doi: 10.5056/jnm.2011.17.1.98.

Chirila I, Morariu ID, Barboi OB, Drug VL. The role of diet in the overlap between gastroesophageal reflux disease and functional dyspepsia . Turk J Gastroenterol. 2016;27:73-80. doi: 10.5152/tjg.2015.150238.

Vasylev YuV. Gastroesophageal reflux disease: Pathogenesis and clinical picture. Mezhdunarodnyj medicinskij zhurnal. 2003;9(1):31-4. (In Rusian).

Dudnykova EV. Clinical significance of biliary reflux in the formation of gastroesophageal reflux disease and gastroduodenitis in children and methods for their correction. Klynycheskіe perspektyvу hastroenterolohyy, hepatolohyy. 2006;5:28-31.(In Russian).

Pakhomovskaia NL. Klynycheskoe znachenye sutochnoi rN-metryy pry hastroezofahealnoi refliuksnoi bolezny u detei [Clinical value of daily pH-metry in gastroesophageal reflux disease in children]. Moscow; 2006. 17 p.

Uspenskyi YuP, Tkachenko EY. Pathogenetic basis of differentiated tactics of treatment of gastroesophageal reflux disease. Suchasna hastroenterolohiia. 2010;1(51):92-100. (In Russian).

Kovalenko AA, Belmer SV. Gastroesophageal reflux disease. Lechashchyi vrach. 2008;1. (In Russian).

Kriuchko TA, Nesyna YM. Optimization of diagnosing gastroesophageal reflux disease in adolescents using GerdQ questionnaire. Zdorov'ye Rebenka. 2015;7(67):97-100. (In Ukrainian). doi.org/10.22141/2224-0551.7.67.2015.75114.

Sheptulyn AA. Gastroesophageal reflux disease: controversial and unresolved issues. Klynycheskaia medytsyna. 2008;6:7-12. (In Russian).

Starets YeA, Trukhalskaia VV. Step-by-step diagnosis for pathological gastroesophageal reflux in children. Zdorov’ye Rebenka. 2015;4(64):47-51. (In Russian). doi: 10.22141/2224-0551.4.64.2015.75320.

Niankovskyi SL, Sadova OR. Dynamics of parameters of quality of life in gastroesophageal reflux disease in adolescents. Aktualni pytannia pediatrii, akusherstva ta hinekolohii. 2015;2:48-50. (In Ukrainian). doi: 10.11603/24116-4944.2015.2.4770.

Vandenplas Y, Rudolph CD, Di Lorenzo C, et al. Pediatric gastroesophageal reflux c linical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology , Hepatology, and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr. 2009 Oct;49(4):498-547. doi: 10.1097/MPG.0b013e3181b7f563.

Jung HK. Epidemiology of gastroesophageal reflux disease in Asia: a systematic review . J Neurogasteroenterol Motil. 2011;17(1):14-27. doi :10.5056/jnm.2011.17.1.14/

Nikaki K, Woodland P, Sifrim D. Adult and paediatric GERD: diagnosis, phenotypes and avoidance of excess treatments. Nature Reviews Gastroenterology & Hepatology. 2016 Sep;13(9):529-42. doi: 10.1038/nrgastro.2016.109.

Zaviktorina TH. Stryha EV, Sokolova YuB, Shumeiko NK, Soldatskii UL. Features of the course of gastroesophageal reflux disease in children. Lechashchyi vrach. — 2008;7:88-9.




DOI: https://doi.org/10.22141/2224-0551.12.2.1.2017.100991

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