Correlations and Prognostic Values of Antiendotoxin Immunity in Children with Different Stages of Septic Process during Treatment

L.F. Pritulo, Yu.A. Bisyuk, T.G. Filonenko, O.V. Vasiliev

Abstract


There were researched 91 children with gram-negative sepsis. All patients have been selected by a random way into 2 groups. The first group included children received pathogenetic immune correction with donors’ plasma enriched with the antibodies to endotoxin; the second group consisted of children who got complex treatment only. The different stages of gram-negative sepsis lead to acute deviation of antiendotoxin immune deficiency which manifested with immune deficiency of specific anti-ET-IgG and ascending primary (low-affinity) anti-ET-IgM under excessive activation of non-specific components LBP and sCD14. Surgical treatment with adequate sanitation of purulent focus in the affected organ, based on prognostic criteria developed and immunomodulation led to a rapid regression of clinical signs of disease and made possible to increase a clinical efficacy of the therapy.

Keywords


endotoxin, immunity, gram-negative sepsis, immunocorrection

References


Martinot A.A., Lecler F., Crener C. et al. Sepsis in neonates and children: Definition, epidemiology, and outcomes // Pediatr. Emerg. Care. — 1997. — Vol. 13. — P. 277-281.

Коэн Д. Современный подход к лечению сепсиса: есть новые надежды? / Д. Коэн // Клиническая микробиология и антимикробная химиотерапия. — 2002. — № 4. — С. 300-312.

Fan H., Cook J.A. Molecular mechanisms of endotoxin tolerance // J. Endotoxin. Res. — 2004. — Vol. 10. — P. 71-84.

Chen G., Li J., Ochani M., Rendon-Mitchell B., Qiang X. et al. Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms // J. Leukoc. Biol. — 2004. — Vol. 76, № 5. — P. 994-1001.

Gioannini T.L., Teghanemt A., Zarember K.A., Weiss J.P. Regulation of interactions of endotoxin with host cells // J. Endotoxin. Res. — 2003. — Vol. 9, № 6. — P. 401-408.

Zapata-Quintanilla L.B., Palmeira P., Tino-De-Franco M., Amaral J.A., Carbonare C.B., Carbonare S.B. Systemic antibody response to diarrheagenic Escherichia coli and LPS O111, O157 and O55 in healthy Brazilian adults // Scand. J. Immunol. — 2006. — Vol. 64(6). — P. 661-7.

Down J.F., Barclay G.R., Bennett-Guerrero E., Hamilton-Davies C. et al. A descriptive study of the variation in baseline levels of antiendotoxin core antibodies between US and UK populations // J. Endotoxin. Res. — 2004. — Vol. 10, № 3. — P. 195-198.

Albertson T.E., Panacek E.A., MacArthur R.D. et al. Multicenter evaluation оf a human monoclonal antibody to Enterobacteriaceae common antigen in patients with Gramnegative sepsis. // Crit. Care Med. — 2003. — Vol. 31. — P. 419-427.

Alejandria M.M., Lansang M.A., Dans L.F., Mantaring J.B.V. Intravenous immunoglobulin for treating sepsis and septic shock (Cochrane review) // The Cochrane Library. — 2002. — Issue 4. Oxford: Update Software.

Goldstein B., Giroir B., Randolph A. et al. International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics // Pediatr. Crit. Care Med. — 2005. — Vol. 6. — P. 2-8.

Спосіб визначення антитіл до ліпополісахаридів грамнегативних бактерій / А.І. Гордієнко, В.О. Білоглазов. — Патент 70193 А Україна МКІ 7 А61К31/01; Заявл. 29.12.2003; Опубл. 15.09.2004, Бюл. № 9.

Tiirola T., Jaakkola A., Bloigu A., Paldanius M., Sinisalo J., Nieminen M.S., Silvennoinen-Kassinen S., Saikku P., Jauhiainen M., Leinonen M. Novel enzyme immunoassay utilizing lipopolysaccharide-binding protein as a capture molecule for the measurement of chlamydial lipopolysaccharide in serum // Diagn. Microbiol. Infect. Dis. — 2006. — Vol. 54(1). — P. 7-12.




DOI: https://doi.org/10.22141/2224-0551.0.4.39.2012.100961

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