Content of Pro- and Anti-inflammatory Cytokines in Blood Serum of Children with Bronchial Asthma of Various Severity

O.I. Smiyan, V.O. Kurganska, O.P. Moshchych, P.I. Sichnenko, V.A. Gorbas


The paper presents the findings of investigation of content of proinflammatory interleukin-1 and anti-inflammatory interleukin-4 in blood serum of children with asthma in the dynamics of disease and dependence of their level on severity of illness. Determination of these cytokines concentration was carried out in 86 children aged from 13 to 18 years. Comparison group consisted of 20 relatively healthy children of appropriate age and gender.
We have established a significant increase of both cytokines level in blood serum, which was most pronounced in acute bronchial asthma, but remained high after standard treatment and remission achieved by patients. There have been define the dependence of disorders on the severity of the disease.


bronchial asthma, cytokines, interleukin-1, interleukin-4


Кетлинский С.А. Цитокины / Кетлинский С.А., Симбирцев А.С. — СПб.: ООО «Издательство Фолиант», 2008. — 552 с.

Чернушенко Е.Ф. Иммунология бронхиальной астмы // Укр. пульмонол. журн. — 2000. — № 2. — С. 19-21.

Юлиш Е.И. Антигистаминные средства в практике лечения аллергических заболеваний / Е.И. Юлиш // Здоровье ребенка. — 2011. — № 3(30). — С. 83-89.

Robert F. Lemanske Jr., MD, William W. Busse, MD Asthma: Clinical expression and molecular mechanisms // The Journal of Allergy and Clinical Immunology. — 2010 Feb. — Vol. 125, № 2. — Р. 95-102.

Copyright (c) 2017 CHILD`S HEALTH

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2018


   Seo анализ сайта